Elevated serum glucose levels and survival after acute heart failure: a population-based perspective
Department of Quantitative Health Sciences; Department of Medicine, Division of Cardiovascular Medicine; Department of Medicine, Division of Geriatric Medicine; Meyers Primary Care Institute; Senior Scholars Program
Cardiology | Cardiovascular Diseases | Clinical Epidemiology | Endocrine System Diseases | Endocrinology, Diabetes, and Metabolism | Epidemiology
BACKGROUND: Limited data are available about the characteristics, treatment and survival in patients without diabetes mellitus (DM), previously diagnosed DM and patients with hyperglycaemia who present with acute decompensated heart failure (ADHF). Our objectives were to examine differences in these endpoints in patients hospitalized with ADHF.
METHODS: Patients hospitalized with ADHF during 1995, 2000, 2002 and 2004 comprised the study population.
RESULTS: A total of 5428 non-diabetic patients were hospitalized with ADHF, 3807 with diagnosed DM and 513 with admission hyperglycaemia. Patients with admission hyperglycaemia experienced the highest in-hospital death rates (9.9%) compared to those with diagnosed DM (6.5%) and non-diabetics (7.5%). Patients with diagnosed DM had the greatest risk of dying after hospital discharge.
CONCLUSIONS: Patients with elevated blood glucose levels at hospital admission are more likely to die acutely. After resolution of the acute illness, patients with previously diagnosed DM need careful monitoring and enhanced treatment.
DOI of Published Version
Diab Vasc Dis Res. 2015 Mar;12(2):119-25. doi: 10.1177/1479164114559024. Epub 2014 Dec 18. Link to article on publisher's site
Diabetes and vascular disease research
Helfand, Benjamin K. I.; Maselli, Nicholas J.; Lessard, Darleen M.; Yarzebski, Jorge L.; Gore, Joel M.; McManus, David D.; Saczynski, Jane S.; and Goldberg, Robert J., "Elevated serum glucose levels and survival after acute heart failure: a population-based perspective" (2015). University of Massachusetts Medical School Faculty Publications. 634.