UMass Chan Medical School Faculty Publications


Multipronged CD4(+) T-cell effector and memory responses cooperate to provide potent immunity against respiratory virus

UMMS Affiliation

Department of Pathology

Publication Date


Document Type



Animals; CD4-Positive T-Lymphocytes; Cytokines; Gene Expression Regulation; Humans; *Immunologic Memory; Influenza A virus; Influenza, Human; Orthomyxoviridae Infections; Respiratory Tract Infections; Transcription Factors; Virus Diseases; Viruses


Cells | Immunology and Infectious Disease | Pathology | Respiratory Tract Diseases | Virus Diseases | Viruses


Over the last decade, the known spectrum of CD4(+) T-cell effector subsets has become much broader, and it has become clear that there are multiple dimensions by which subsets with a particular cytokine commitment can be further defined, including their stage of differentiation, their location, and, most importantly, their ability to carry out discrete functions. Here, we focus on our studies that highlight the synergy among discrete subsets, especially those defined by helper and cytotoxic function, in mediating viral protection, and on distinctions between CD4(+) T-cell effectors located in spleen, draining lymph node, and in tissue sites of infection. What emerges is a surprising multiplicity of CD4(+) T-cell functions that indicate a large arsenal of mechanisms by which CD4(+) T cells act to combat viruses.

DOI of Published Version



Immunol Rev. 2013 Sep;255(1):149-64. doi: 10.1111/imr.12088. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Immunological reviews

PubMed ID