Different kenyon cell populations drive learned approach and avoidance in Drosophila
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Student Authors
Suewei LinAcademic Program
NeuroscienceDocument Type
Journal ArticlePublication Date
2013-09-04Keywords
AnimalsAppetitive Behavior
Avoidance Learning
Behavior, Animal
Dopaminergic Neurons
Drosophila
Learning
Memory
Mushroom Bodies
Smell
Drosophila melanogaster
Memory
Smell
Learning
Behavioral Neurobiology
Molecular and Cellular Neuroscience
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Show full item recordAbstract
In Drosophila, anatomically discrete dopamine neurons that innervate distinct zones of the mushroom body (MB) assign opposing valence to odors during olfactory learning. Subsets of MB neurons have temporally unique roles in memory processing, but valence-related organization has not been demonstrated. We functionally subdivided the alphabeta neurons, revealing a value-specific role for the approximately 160 alphabeta core (alphabetac) neurons. Blocking neurotransmission from alphabeta surface (alphabetas) neurons revealed a requirement during retrieval of aversive and appetitive memory, whereas blocking alphabetac only impaired appetitive memory. The alphabetac were also required to express memory in a differential aversive paradigm demonstrating a role in relative valuation and approach behavior. Strikingly, both reinforcing dopamine neurons and efferent pathways differentially innervate alphabetac and alphabetas in the MB lobes. We propose that conditioned approach requires pooling synaptic outputs from across the alphabeta ensemble but only from the alphabetas for conditioned aversion.Source
Neuron. 2013 Sep 4;79(5):945-56. doi: 10.1016/j.neuron.2013.07.045. Link to article on publisher's siteDOI
10.1016/j.neuron.2013.07.045Permanent Link to this Item
http://hdl.handle.net/20.500.14038/30325PubMed ID
24012007Related Resources
Link to Article in PubMedDistribution License
http://creativecommons.org/licenses/by-nc-nd/3.0/ae974a485f413a2113503eed53cd6c53
10.1016/j.neuron.2013.07.045
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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-nd/3.0/