University of Massachusetts Medical School Faculty Publications
UMMS Affiliation
Department of Neurobiology; Waddell Lab
Publication Date
2013-09-04
Document Type
Article
Subjects
Animals; Appetitive Behavior; Avoidance Learning; Behavior, Animal; Dopaminergic Neurons; Drosophila; Learning; Memory; Mushroom Bodies; Smell
Disciplines
Behavioral Neurobiology | Molecular and Cellular Neuroscience
Abstract
In Drosophila, anatomically discrete dopamine neurons that innervate distinct zones of the mushroom body (MB) assign opposing valence to odors during olfactory learning. Subsets of MB neurons have temporally unique roles in memory processing, but valence-related organization has not been demonstrated. We functionally subdivided the alphabeta neurons, revealing a value-specific role for the approximately 160 alphabeta core (alphabetac) neurons. Blocking neurotransmission from alphabeta surface (alphabetas) neurons revealed a requirement during retrieval of aversive and appetitive memory, whereas blocking alphabetac only impaired appetitive memory. The alphabetac were also required to express memory in a differential aversive paradigm demonstrating a role in relative valuation and approach behavior. Strikingly, both reinforcing dopamine neurons and efferent pathways differentially innervate alphabetac and alphabetas in the MB lobes. We propose that conditioned approach requires pooling synaptic outputs from across the alphabeta ensemble but only from the alphabetas for conditioned aversion.
Keywords
Drosophila melanogaster, Memory, Smell, Learning
DOI of Published Version
10.1016/j.neuron.2013.07.045
Source
Neuron. 2013 Sep 4;79(5):945-56. doi: 10.1016/j.neuron.2013.07.045. Link to article on publisher's site
Related Resources
Journal/Book/Conference Title
Neuron
PubMed ID
24012007
Repository Citation
Perisse, Emmanuel; Yin, Yan; Lin, Andrew C.; Lin, Suewei; Huetteroth, Wolf; and Waddell, Scott, "Different kenyon cell populations drive learned approach and avoidance in Drosophila" (2013). University of Massachusetts Medical School Faculty Publications. 595.
https://escholarship.umassmed.edu/faculty_pubs/595
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.