UMass Chan Medical School Faculty Publications
Title
Shiga toxin-producing Escherichia coli O104:H4: an emerging pathogen with enhanced virulence
UMMS Affiliation
Department of Microbiology and Physiological Systems; Department of Pathology
Publication Date
2013-09-10
Document Type
Article
Subjects
Communicable Diseases, Emerging; Disease Outbreaks; Escherichia coli Infections; Europe; Genome, Bacterial; Humans; Shiga-Toxigenic Escherichia coli; Virulence
Disciplines
Bacteria | Digestive System Diseases | Immunology and Infectious Disease | Microbiology | Pathogenic Microbiology
Abstract
Pathogenic Escherichia coli are genetically diverse and encompass a broad variety of pathotypes, such as enteroaggregative E. coli (EAEC) or enterohemorrhagic E. coli (EHEC), which cause distinct clinical syndromes. The historically large 2011 German outbreak of hemolytic uremic syndrome (HUS), caused by a Shiga-toxin producing E. coli (STEC) of the serotype O104:H4, illustrated the emerging importance of non-O157 STEC. STEC O104:H4, with features characteristic of both enteroaggregative E. coli and enterohemorrhagic E. coli, represents a unique and highly virulent pathotype. The German outbreak both allowed for the evaluation of several potential therapeutic approaches to STEC-induced HUS and emphasizes the importance of early and specific detection of both O157 and non-O157 STEC.
DOI of Published Version
10.1016/j.idc.2013.05.002
Source
Infect Dis Clin North Am. 2013 Sep;27(3):631-49. doi: 10.1016/j.idc.2013.05.002. Epub 2013 Jul 24. Link to article on publisher's site
Related Resources
Journal/Book/Conference Title
Infectious disease clinics of North America
PubMed ID
24011834
Repository Citation
Jandhyala DM, Vanguri VK, Boll EJ, Lai Y(, McCormick BA, Leong JM. (2013). Shiga toxin-producing Escherichia coli O104:H4: an emerging pathogen with enhanced virulence. UMass Chan Medical School Faculty Publications. https://doi.org/10.1016/j.idc.2013.05.002. Retrieved from https://escholarship.umassmed.edu/faculty_pubs/575