Title

Malignancy and acute pulmonary embolism: risk stratification including the right to left ventricle diameter ratio in 1596 subjects

Authors

Bryan Cai, Brigham and Women's Hospital
Arash Bedayat, University of Massachusetts Medical SchoolFollow
Elizabeth George, Brigham and Women's Hospital
Andetta R. Hunsaker, Brigham and Women's Hospital
Karin E. Dill, Brigham and Women's Hospital
Frank J. Rybicki, Harvard Medical School
Kanako K. Kumamaru, Brigham and Women's Hospital

UMMS Affiliation

Department of Radiology

Publication Date

2013-5

Document Type

Article

Subjects

Pulmonary Embolism; Neoplasms

Disciplines

Cardiovascular Diseases | Neoplasms | Oncology | Radiology | Respiratory Tract Diseases

Abstract

PURPOSE: To test the hypothesis that subjects with a known malignancy at the time of acute pulmonary embolism (PE) have different clinical characteristics and predictors of 30-day all-cause mortality when compared with subjects with no known malignancy.

MATERIALS AND METHODS: A retrospective (August 2003 to March 2010) cohort of 1596 consecutive positive (for acute PE) computed tomography pulmonary angiograms (CTPAs) performed at a single, large, urban teaching hospital was separated into those from subjects with (n=835) and those from subjects without (n=761) a known malignancy. Clinical characteristics were compared between groups, and a logistic regression model determined predictors of 30-day all-cause mortality for each group.

RESULTS: Subjects with malignancy were older (60.8+/-13.9 vs. 54.5+/-18.8 y, P1.0) had a higher risk of 30-day death only among subjects with no known malignancy at the time of the CTPA (odds ratio=4.08, 95% confidence interval: 1.67-9.96).

CONCLUSIONS: Among subjects who present with acute PE, those with a malignancy had different clinical characteristics and predictors of mortality when compared with the cohort of subjects with no known malignancy. A computed tomography-derived right to left ventricular diameter ratio predicts 30-day all-cause mortality only for those subjects who do not have a malignancy.

DOI of Published Version

10.1097/RTI.0b013e3182870bf9

Source

J Thorac Imaging. 2013 May;28(3):196-201. doi: 10.1097/RTI.0b013e3182870bf9. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Journal of thoracic imaging

PubMed ID

23478511

Repository Citation

Cai B, Bedayat A, George E, Hunsaker AR, Dill KE, Rybicki FJ, Kumamaru KK. (2013). Malignancy and acute pulmonary embolism: risk stratification including the right to left ventricle diameter ratio in 1596 subjects. UMass Chan Medical School Faculty Publications. https://doi.org/10.1097/RTI.0b013e3182870bf9. Retrieved from https://escholarship.umassmed.edu/faculty_pubs/57