University of Massachusetts Medical School Faculty Publications


Increased risk of mucinous neoplasm of the appendix in adults undergoing interval appendectomy

UMMS Affiliation

Department of Surgery

Publication Date


Document Type



Adenocarcinoma, Mucinous; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; *Appendectomy; Appendiceal Neoplasms; Appendicitis; Carcinoid Tumor; Cystadenoma, Mucinous; Female; Humans; Incidence; Male; Middle Aged; Retrospective Studies; Risk Factors; Young Adult


Digestive System Diseases | Neoplasms | Oncology | Surgery


IMPORTANCE: The role of interval appendectomy after conservative management of perforated appendicitis remains controversial. Determining the etiology of perforated appendicitis is one reason to perform interval appendectomies.

OBJECTIVE: To determine whether adult patients undergoing interval appendectomy experience an increased rate of neoplasms.

DESIGN: Retrospective study.

SETTING: A single tertiary care institution.

PARTICIPANTS: All patients 18 years or older who underwent appendectomy for presumed appendicitis from January 1, 2006, through December 31, 2010.

EXPOSURES Appendectomy for presumed appendicitis.

MAIN OUTCOMES AND MEASURES: Underlying neoplasm as the cause of presentation for presumed appendicitis. Demographic data, clinicopathologic characteristics, interval resection rate, and complication data were collected and analyzed.

RESULTS: During the study period, 376 patients underwent appendectomies. Interval appendectomy was performed in 17 patients (4.5%). Neoplasms were identified in 14 patients (3.7%); 5 of those tumors occurred in patients who had undergone interval appendectomy (29.4%). Nine neoplasms were mucinous tumors (64.3%), including all neoplasms associated with interval appendectomies. The mean age of all patients with appendiceal tumors was 49 years (range, 35-74 years).

CONCLUSIONS AND RELEVANCE: Mucinous neoplasms of the appendix were found in 5 of 17 patients (29.4%) undergoing interval appendectomy. Interval appendectomies should be considered in all adult patients, especially those 40 years or older, to determine the underlying cause of appendicitis. A multi-institutional study to determine the generalizability of these findings is warranted.

DOI of Published Version



JAMA Surg. 2013 Aug;148(8):703-6. doi: 10.1001/jamasurg.2013.1212. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

JAMA surgery

PubMed ID