University of Massachusetts Medical School Faculty Publications

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Department of Pathology

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Animals; Embryonic Development; Gene Expression Regulation; Humans; Inflammation; Necrosis; Neoplasms; Protein Processing, Post-Translational; Receptor-Interacting Protein Serine-Threonine Kinases; Signal Transduction


Cellular and Molecular Physiology | Developmental Biology | Immunopathology | Molecular Genetics | Pathology


The receptor-interacting protein kinase 3 (RIP3/RIPK3) has emerged as a critical regulator of programmed necrosis/necroptosis, an inflammatory form of cell death with important functions in pathogen-induced and sterile inflammation. RIP3 activation is tightly regulated by phosphorylation, ubiquitination, and caspase-mediated cleavage. These post-translational modifications coordinately regulate the assembly of a macromolecular signaling complex termed the necrosome. Recently, several reports indicate that RIP3 can promote inflammation independent of its pronecrotic activity. Here, we review our current understanding of the mechanisms that drive RIP3-dependent necrosis and its role in different inflammatory diseases.


FADD, MLKL, PGAM5, RIP1, caspase 8, inflammation

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DOI of Published Version



Genes Dev. 2013 Aug 1;27(15):1640-9. doi: 10.1101/gad.223321.113. Link to article on publisher's site

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Link to Article in PubMed

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Genes and development

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Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License



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