University of Massachusetts Medical School Faculty Publications
UMMS Affiliation
Department of Pathology
Publication Date
8-1-2013
Document Type
Article
Subjects
Animals; Embryonic Development; Gene Expression Regulation; Humans; Inflammation; Necrosis; Neoplasms; Protein Processing, Post-Translational; Receptor-Interacting Protein Serine-Threonine Kinases; Signal Transduction
Disciplines
Cellular and Molecular Physiology | Developmental Biology | Immunopathology | Molecular Genetics | Pathology
Abstract
The receptor-interacting protein kinase 3 (RIP3/RIPK3) has emerged as a critical regulator of programmed necrosis/necroptosis, an inflammatory form of cell death with important functions in pathogen-induced and sterile inflammation. RIP3 activation is tightly regulated by phosphorylation, ubiquitination, and caspase-mediated cleavage. These post-translational modifications coordinately regulate the assembly of a macromolecular signaling complex termed the necrosome. Recently, several reports indicate that RIP3 can promote inflammation independent of its pronecrotic activity. Here, we review our current understanding of the mechanisms that drive RIP3-dependent necrosis and its role in different inflammatory diseases.
Keywords
FADD, MLKL, PGAM5, RIP1, caspase 8, inflammation
Rights and Permissions
Publisher PDF posted as allowed by the publisher's author rights policy at http://genesdev.cshlp.org/site/misc/terms.xhtml.
DOI of Published Version
10.1101/gad.223321.113
Source
Genes Dev. 2013 Aug 1;27(15):1640-9. doi: 10.1101/gad.223321.113. Link to article on publisher's site
Related Resources
Journal/Book/Conference Title
Genes and development
PubMed ID
23913919
Repository Citation
Moriwaki, Kenta and Chan, Francis Ka-Ming, "RIP3: a molecular switch for necrosis and inflammation" (2013). University of Massachusetts Medical School Faculty Publications. 534.
https://escholarship.umassmed.edu/faculty_pubs/534
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
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Cellular and Molecular Physiology Commons, Developmental Biology Commons, Immunopathology Commons, Molecular Genetics Commons, Pathology Commons