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UMass Chan Affiliations
Department of Microbiology and Physiological SystemsDocument Type
Journal ArticlePublication Date
2013-10-01Keywords
AnimalsGlobal Health
Humans
Influenza A virus
Influenza, Human
Pandemics
Virulence
Genetics
Immunology and Infectious Disease
Immunopathology
Virology
Metadata
Show full item recordAbstract
Despite effective vaccines, influenza remains a major global health threat due to the morbidity and mortality caused by seasonal epidemics, as well as the 2009 pandemic. Also of profound concern are the rare but potentially catastrophic transmissions of avian influenza to humans, highlighted by a recent H7N9 influenza outbreak. Murine and human studies reveal that the clinical course of influenza is the result of a combination of both host and viral genetic determinants. While viral pathogenicity has long been the subject of intensive efforts, research to elucidate host genetic determinants, particularly human, is now in the ascendant, and the goal of this review is to highlight these recent insights.Source
Curr Opin Virol. 2013 Oct;3(5):531-6. doi: 10.1016/j.coviro.2013.07.005. Epub 2013 Aug 8. Link to article on publisher's siteDOI
10.1016/j.coviro.2013.07.005Permanent Link to this Item
http://hdl.handle.net/20.500.14038/30262PubMed ID
23933004Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.coviro.2013.07.005