Shifting fitness landscapes in response to altered environments
Department of Biochemistry and Molecular Pharmacology; Program in Bioinformatics and Integrative Biology
Adaptation, Physiological; *Environment; Evolution, Molecular; *Genetic Fitness; HSP90 Heat-Shock Proteins; Point Mutation; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; *Selection, Genetic
Computational Biology | Ecology and Evolutionary Biology | Integrative Biology | Population Biology
The role of adaptation in molecular evolution has been contentious for decades. Here, we shed light on the adaptive potential in Saccharomyces cerevisiae by presenting systematic fitness measurements for all possible point mutations in a region of Hsp90 under four environmental conditions. Under elevated salinity, we observe numerous beneficial mutations with growth advantages up to 7% relative to the wild type. All of these beneficial mutations were observed to be associated with high costs of adaptation. We thus demonstrate that an essential protein can harbor adaptive potential upon an environmental challenge, and report a remarkable fit of the data to a version of Fisher's geometric model that focuses on the fitness trade-offs between mutations in different environments. Evolution.
DOI of Published Version
Evolution. 2013 Dec;67(12):3512-22. doi: 10.1111/evo.12207. Epub 2013 Aug 2. Link to article on publisher's site
Evolution; international journal of organic evolution
Hietpas, Ryan T.; Bank, Claudia; Jensen, Jeffrey D.; and Bolon, Daniel N. A., "Shifting fitness landscapes in response to altered environments" (2013). University of Massachusetts Medical School Faculty Publications. 505.