UMass Chan Medical School Faculty Publications


Clinical implications of current developments in genitourinary pathology

UMMS Affiliation

Department of Pathology

Publication Date


Document Type



Adenocarcinoma; Carcinoma, Renal Cell; Humans; In Situ Hybridization, Fluorescence; Kidney Neoplasms; Male; Oncogene Proteins, Fusion; Pathology; Prostatic Neoplasms; Proto-Oncogene Proteins c-ets; RNA-Binding Proteins; Translational Medical Research; Tumor Markers, Biological; Urinary Bladder Neoplasms


Male Urogenital Diseases | Neoplasms | Pathology | Urogenital System


CONTEXT: Several developments in genitourinary pathology are likely to change our understanding and management of some genitourinary cancers considerably.

OBJECTIVE: To review 5 stories in genitourinary pathology: (1) fusion in the ETS (E26) gene family in prostatic adenocarcinoma; (2) insulin-like growth factor II messenger RNA-binding protein 3 (IMP3), an important prognostic biomarker for kidney and bladder cancers; (3) translocation renal cell carcinoma; (4) UroVysion fluorescence in situ hybridization test in urine cytology for detection of bladder cancer; and (5) the use of triple immunostaining for diagnosis of prostate cancer.

DATA SOURCES: Literature review and authors' personal experiences.

CONCLUSIONS: Many scientific findings have contributed recently to the understanding of the natural pathogenesis and progression of genitourinary cancers. This translational research helps in diagnosing, predicting, and potentially, treating genitourinary cancers.

DOI of Published Version



Arch Pathol Lab Med. 2013 Jul;137(7):887-93. doi: 10.5858/arpa.2012-0210-RA. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Archives of pathology and laboratory medicine

PubMed ID