University of Massachusetts Medical School Faculty Publications
Title
Circulating levels of soluble MICB in infants with symptomatic primary dengue virus infections
UMMS Affiliation
Department of Medicine, Division of Immunology and Infectious Diseases
Publication Date
2014-05-28
Document Type
Article
Disciplines
Immunology of Infectious Disease | Immunoprophylaxis and Therapy | Virus Diseases
Abstract
Dengue is the most prevalent arthropod-borne viral illness in humans. A MHC class I polypeptide-related sequence B (MICB) single nucleotide polymorphism (SNP) was previously associated with symptomatic dengue compared to non-dengue causes of acute febrile illnesses in infants. We measured circulating levels of soluble (s)MICB in the sera of infants with symptomatic primary dengue virus infections. We found that serum levels of sMICB increased between pre-infection and acute illness among infants with symptomatic primary dengue virus infections. The likelihood of being hospitalized with an acute primary DENV infection during infancy also tended to be higher with increasing acute illness sMICB levels. The elevation of sMICB during acute primary DENV infections in infants likely represents an immune evasion strategy and contributes to the severity of the acute illness.
Rights and Permissions
© 2014 Libraty et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI of Published Version
10.1371/journal.pone.0098509
Source
PLoS One. 2014 May 28;9(5):e98509. doi: 10.1371/journal.pone.0098509. eCollection 2014. Link to article on publisher's site
Related Resources
Journal/Book/Conference Title
PloS one
PubMed ID
24869966
Repository Citation
Libraty, Daniel H.; Zhang, Lei; Obcena, AnaMae; Brion, Job D.; and Capeding, Rosario Z., "Circulating levels of soluble MICB in infants with symptomatic primary dengue virus infections" (2014). University of Massachusetts Medical School Faculty Publications. 425.
https://escholarship.umassmed.edu/faculty_pubs/425
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Included in
Immunology of Infectious Disease Commons, Immunoprophylaxis and Therapy Commons, Virus Diseases Commons