University of Massachusetts Medical School Faculty Publications
Title
A perspective on recurrent vertigo
UMMS Affiliation
Department of Otolaryngology
Publication Date
2013-07-01
Document Type
Article
Subjects
Humans; *Meniere Disease; Recurrence; Vertigo; *Vestibular Neuronitis
Disciplines
Nervous System Diseases | Otolaryngology | Otorhinolaryngologic Diseases | Pathological Conditions, Signs and Symptoms | Therapeutics
Abstract
The recurrent nature of the 3 most common vestibulopathies suggests a recurrent cause. Histopathology in temporal bones from patients with these syndromes - vestibular neuronitis (VN, n = 7), Meniere's disease (MD, n = 8) and benign paroxysmal positional vertigo (BPPV, n = 5) - shows focal degeneration of vestibular nerve axons and degenerated nearby facial nerve meatal ganglion cells. Transmission electron microscopic confirmation of intracytoplasmic viral particles in surgically excised vestibular nerves from patients with VN and MD support a viral etiology in these vestibulopathies. Antiviral treatment of these syndromes in a series of 211 patients with a 3- to 8-year follow-up resulted in complete control of vertigo in VN (88%), MD (90%) and BPPV (60%).
Keywords
Vertigo, Viral etiology, Positional vertigo
DOI of Published Version
10.1159/000348710
Source
Gacek RR. A perspective on recurrent vertigo. ORL J Otorhinolaryngol Relat Spec. 2013;75(2):91-107. doi: 10.1159/000348710. Link to article on publisher's site
Related Resources
Journal/Book/Conference Title
ORL; journal for oto-rhino-laryngology and its related specialties
PubMed ID
23796949
Repository Citation
Gacek RR. (2013). A perspective on recurrent vertigo. University of Massachusetts Medical School Faculty Publications. https://doi.org/10.1159/000348710. Retrieved from https://escholarship.umassmed.edu/faculty_pubs/414