Preclinical investigations for thrombectomy devices--does it translate to humans
Department of Radiology
Angiography, Digital Subtraction; Animals; Cerebral Angiography; Cerebrovascular Circulation; Device Approval; Disease Models, Animal; Dogs; Female; Humans; Male; Microscopy, Electron, Scanning; Models, Anatomic; Safety; Stroke; Thrombectomy; United States; United States Food and Drug Administration
Cardiovascular Diseases | Nervous System Diseases | Neurology | Radiology | Surgical Procedures, Operative
Currently, most preclinical models to validate thrombectomy technologies have not directly translated to the clinical arena. Herein, we review our strategy that combines in vitro and in vivo modeling to assess thrombectomy device safety and efficacy quantitatively.
Acute ischemic stroke, clot, embolic shower, preclinical modeling, recanalization, thrombectomy
DOI of Published Version
Gounis MJ, Wakhloo AK, Chueh JY. Preclinical investigations for thrombectomy devices--does it translate to humans? Stroke. 2013 Jun;44(6 Suppl 1):S7-S10. doi: 10.1161/STROKEAHA.111.000692. Link to article on publisher's site
Stroke; a journal of cerebral circulation
Gounis, Matthew J.; Wakhloo, Ajay K.; and Chueh, Juyu, "Preclinical investigations for thrombectomy devices--does it translate to humans" (2013). University of Massachusetts Medical School Faculty Publications. 412.