University of Massachusetts Medical School Faculty Publications

Title

Preclinical investigations for thrombectomy devices--does it translate to humans

UMMS Affiliation

Department of Radiology

Publication Date

6-5-2013

Document Type

Article

Subjects

Angiography, Digital Subtraction; Animals; Cerebral Angiography; Cerebrovascular Circulation; Device Approval; Disease Models, Animal; Dogs; Female; Humans; Male; Microscopy, Electron, Scanning; Models, Anatomic; Safety; Stroke; Thrombectomy; United States; United States Food and Drug Administration

Disciplines

Cardiovascular Diseases | Nervous System Diseases | Neurology | Radiology | Surgical Procedures, Operative

Abstract

Currently, most preclinical models to validate thrombectomy technologies have not directly translated to the clinical arena. Herein, we review our strategy that combines in vitro and in vivo modeling to assess thrombectomy device safety and efficacy quantitatively.

Keywords

Acute ischemic stroke, clot, embolic shower, preclinical modeling, recanalization, thrombectomy

DOI of Published Version

10.1161/STROKEAHA.111.000692

Source

Gounis MJ, Wakhloo AK, Chueh JY. Preclinical investigations for thrombectomy devices--does it translate to humans? Stroke. 2013 Jun;44(6 Suppl 1):S7-S10. doi: 10.1161/STROKEAHA.111.000692. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Stroke; a journal of cerebral circulation

PubMed ID

23709736

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