University of Massachusetts Medical School Faculty Publications
Title
Preclinical investigations for thrombectomy devices--does it translate to humans
UMMS Affiliation
Department of Radiology
Publication Date
6-5-2013
Document Type
Article
Subjects
Angiography, Digital Subtraction; Animals; Cerebral Angiography; Cerebrovascular Circulation; Device Approval; Disease Models, Animal; Dogs; Female; Humans; Male; Microscopy, Electron, Scanning; Models, Anatomic; Safety; Stroke; Thrombectomy; United States; United States Food and Drug Administration
Disciplines
Cardiovascular Diseases | Nervous System Diseases | Neurology | Radiology | Surgical Procedures, Operative
Abstract
Currently, most preclinical models to validate thrombectomy technologies have not directly translated to the clinical arena. Herein, we review our strategy that combines in vitro and in vivo modeling to assess thrombectomy device safety and efficacy quantitatively.
Keywords
Acute ischemic stroke, clot, embolic shower, preclinical modeling, recanalization, thrombectomy
DOI of Published Version
10.1161/STROKEAHA.111.000692
Source
Gounis MJ, Wakhloo AK, Chueh JY. Preclinical investigations for thrombectomy devices--does it translate to humans? Stroke. 2013 Jun;44(6 Suppl 1):S7-S10. doi: 10.1161/STROKEAHA.111.000692. Link to article on publisher's site
Related Resources
Journal/Book/Conference Title
Stroke; a journal of cerebral circulation
PubMed ID
23709736
Repository Citation
Gounis, Matthew J.; Wakhloo, Ajay K.; and Chueh, Juyu, "Preclinical investigations for thrombectomy devices--does it translate to humans" (2013). University of Massachusetts Medical School Faculty Publications. 412.
https://escholarship.umassmed.edu/faculty_pubs/412