Adipose tissue angiogenesis: impact on obesity and type-2 diabetes
Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
UMass Chan Affiliations
Program in Molecular MedicineDocument Type
Journal ArticlePublication Date
2014-03-01Keywords
AdipocytesAdipogenesis
Adipose Tissue
Diabetes Mellitus, Type 2
Humans
Insulin Resistance
Neovascularization, Pathologic
Obesity
Adipocyte
Blood vessel
Capillary
Endothelial
Fat
Vascular
Biochemistry
Cell Biology
Cellular and Molecular Physiology
Developmental Biology
Metadata
Show full item recordAbstract
The growth and function of tissues are critically dependent on their vascularization. Adipose tissue is capable of expanding many-fold during adulthood, therefore requiring the formation of new vasculature to supply growing and proliferating adipocytes. The expansion of the vasculature in adipose tissue occurs through angiogenesis, where new blood vessels develop from those pre-existing within the tissue. Inappropriate angiogenesis may underlie adipose tissue dysfunction in obesity, which in turn increases type-2 diabetes risk. In addition, genetic and developmental factors involved in vascular patterning may define the size and expandability of diverse adipose tissue depots, which are also associated with type-2 diabetes risk. Moreover, the adipose tissue vasculature appears to be the niche for pre-adipocyte precursors, and factors that affect angiogenesis may directly impact the generation of new adipocytes. Here we review recent advances on the basic mechanisms of angiogenesis, and on the role of angiogenesis in adipose tissue development and obesity. A substantial amount of data points to a deficit in adipose tissue angiogenesis as a contributing factor to insulin resistance and metabolic disease in obesity. These emerging findings support the concept of the adipose tissue vasculature as a source of new targets for metabolic disease therapies. This article is part of a Special Issue entitled: Modulation of Adipose Tissue in Health and Disease.Source
Corvera S, Gealekman O. Adipose tissue angiogenesis: impact on obesity and type-2 diabetes. Biochim Biophys Acta. 2014 Mar;1842(3):463-72. doi:10.1016/j.bbadis.2013.06.003. Link to article on publisher's siteDOI
10.1016/j.bbadis.2013.06.003Permanent Link to this Item
http://hdl.handle.net/20.500.14038/30155PubMed ID
23770388Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.bbadis.2013.06.003