UMass Chan Medical School Faculty Publications


Systems biology approach to transplant immune tolerance

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Department of Surgery

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Animals; Humans; *Immune Tolerance; *Systems Biology; T-Lymphocytes; *Transplantation Immunology


Biological Factors | Cells | Genetic Phenomena | Surgery | Surgical Procedures, Operative | Systems Biology


Solid organ transplantation has achieved increased success during the past decade, largely related to advances in immunosuppression and control of acute rejection [1]. However, long-term graft survival has not changed as the result of multiple factors, including irreversible chronic rejection and patient death caused by the side effects of standard immunosuppressive drugs [1]. Tolerance induction thus remains a goal in the field of transplantation. It has been demonstrated that mixed chimerism, a state in which bone marrow cells of different genetic background coexist, is associated with donor-specific transplantation tolerance. Mixed chimerism through nonmyeloablative bone marrow transplantation has been shown to induce tolerance to kidney allografts in humans.

DOI of Published Version



Saidi RF. Systems biology approach to transplant immune tolerance. J Surg Res. 2013 Jun 15;182(2):203-4. doi: 10.1016/j.jss.2012.03.043. Link to article on publisher's site

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Link to Article in PubMed

Journal/Book/Conference Title

The Journal of surgical research

PubMed ID