UMass Chan Medical School Faculty Publications

Title

Systems biology approach to transplant immune tolerance

UMMS Affiliation

Department of Surgery

Publication Date

2013-06-15

Document Type

Response or Comment

Subjects

Animals; Humans; *Immune Tolerance; *Systems Biology; T-Lymphocytes; *Transplantation Immunology

Disciplines

Biological Factors | Cells | Genetic Phenomena | Surgery | Surgical Procedures, Operative | Systems Biology

Abstract

Solid organ transplantation has achieved increased success during the past decade, largely related to advances in immunosuppression and control of acute rejection [1]. However, long-term graft survival has not changed as the result of multiple factors, including irreversible chronic rejection and patient death caused by the side effects of standard immunosuppressive drugs [1]. Tolerance induction thus remains a goal in the field of transplantation. It has been demonstrated that mixed chimerism, a state in which bone marrow cells of different genetic background coexist, is associated with donor-specific transplantation tolerance. Mixed chimerism through nonmyeloablative bone marrow transplantation has been shown to induce tolerance to kidney allografts in humans.

DOI of Published Version

10.1016/j.jss.2012.03.043

Source

Saidi RF. Systems biology approach to transplant immune tolerance. J Surg Res. 2013 Jun 15;182(2):203-4. doi: 10.1016/j.jss.2012.03.043. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

The Journal of surgical research

PubMed ID

22502903

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