UMass Chan Medical School Faculty Publications
Title
Utilization of epidermal growth factor receptor (EGFR) testing in the United States: a case study of T3 translational research
UMMS Affiliation
UMass Center for Clinical and Translational Science
Publication Date
2013-8
Document Type
Article
Disciplines
Community Health and Preventive Medicine | Diagnosis | Genetics and Genomics | Health Services Administration | Medical Genetics | Molecular Genetics | Neoplasms | Respiratory Tract Diseases | Translational Medical Research
Abstract
PURPOSE: We examined hospital use of the epidermal growth factor receptor assay in patients with lung cancer in the United States. Our goal was to inform the development of a model to predict phase 3 translation of guideline-directed molecular diagnostic tests.
METHODS: This was a retrospective observational study. Using logistic regression, we analyzed the association between hospitals' institutional and regional characteristics and the likelihood that an epidermal growth factor receptor assay would be ordered.
RESULTS: Significant institutional predictors included affiliation with an academic medical center (odds ratio, 1.48; 95% confidence interval, 1.20-1.83), participation in a National Cancer Institute clinical research cooperative group (odds ratio, 2.06, 1.66-2.55), and -availability of positron emission tomography scan (odds ratio, 1.44, 1.07-1.94) and cardiothoracic surgery (odds ratio, 1.90, 1.52-2.37) services. Significant regional predictors included metropolitan county (odds ratio, 2.08, 1.48-2.91), population with above-average education (odds ratio, 1.46, 1.09-1.96), and population with above-average income (odds ratio, 1.46, 1.04-2.05). Distance from a National Cancer Institute cancer center was a negative predictor (odds ratio, 0.996, 0.995-0.998), with a 34% decrease in likelihood for every 100 miles.
CONCLUSION: In 2010, only 12% of US acute-care hospitals ordered the epidermal growth factor receptor assay, suggesting that most patients with lung cancer did not have access to this test. This case study illustrated the need for: (i) increased dissemination and implementation research, and (ii) interventions to improve adoption of guideline-directed molecular diagnostic tests by community hospitals.
Keywords
UMCCTS funding, equity, access, lung, cancer, genomics
DOI of Published Version
10.1038/gim.2013.5
Source
Genet Med. 2013 Aug;15(8):630-8. doi: 10.1038/gim.2013.5. Epub 2013 Feb 28. Link to article on publisher's site
Related Resources
Journal/Book/Conference Title
Genetics in medicine : official journal of the American College of Medical Genetics
PubMed ID
23448725
Repository Citation
Lynch JA, Khoury MJ, Borzecki AM, Cromwell J, Hayman LL, Ponte PR, Miller GA, Lathan CS. (2013). Utilization of epidermal growth factor receptor (EGFR) testing in the United States: a case study of T3 translational research. UMass Chan Medical School Faculty Publications. https://doi.org/10.1038/gim.2013.5. Retrieved from https://escholarship.umassmed.edu/faculty_pubs/352