Dietary Magnesium Intake Improves Insulin Resistance among Non-Diabetic Individuals with Metabolic Syndrome Participating in a Dietary Trial
Authors
Wang, JinsongPersuitte, Gioia
Olendzki, Barbara C.
Wedick, Nicole M.
Zhang, Zhiying
Merriam, Philip A.
Fang, Hua Julia
Carmody, James F.
Olendzki, Gin-Fei
Ma, Yunsheng
UMass Chan Affiliations
Department of Quantitative Health SciencesDepartment of Medicine, Division of Preventive and Behavioral Medicine
Document Type
Journal ArticlePublication Date
2013-09-27Keywords
UMCCTS fundingDietetics and Clinical Nutrition
Endocrinology, Diabetes, and Metabolism
Epidemiology
Metadata
Show full item recordAbstract
Many cross-sectional studies show an inverse association between dietary magnesium and insulin resistance, but few longitudinal studies examine the ability to meet the Recommended Dietary Allowance (RDA) for magnesium intake through food and its effect on insulin resistance among participants with metabolic syndrome (MetS). The dietary intervention study examined this question in 234 individuals with MetS. Magnesium intake was assessed using 24-h dietary recalls at baseline, 6, and 12 months. Fasting glucose and insulin levels were collected at each time point; and insulin resistance was estimated by the homeostasis model assessment (HOMA-IR). The relation between magnesium intake and HOMA-IR was assessed using linear mixed models adjusted for covariates. Baseline magnesium intake was 287 +/- 93 mg/day (mean +/- standard deviation), and HOMA-IR, fasting glucose and fasting insulin were 3.7 +/- 3.5, 99 +/- 13 mg/dL, and 15 +/- 13 muU/mL, respectively. At baseline, 6-, and 12-months, 23.5%, 30.4%, and 27.7% met the RDA for magnesium. After multivariate adjustment, magnesium intake was inversely associated with metabolic biomarkers of insulin resistance (P < 0.01). Further, the likelihood of elevated HOMA-IR (>3.6) over time was 71% lower [odds ratio (OR): 0.29; 95% confidence interval (CI): 0.12, 0.72] in participants in the highest quartile of magnesium intake than those in the lowest quartile. For individuals meeting the RDA for magnesium, the multivariate-adjusted OR for high HOMA-IR over time was 0.37 (95% CI: 0.18, 0.77). These findings indicate that dietary magnesium intake is inadequate among non-diabetic individuals with MetS and suggest that increasing dietary magnesium to meet the RDA has a protective effect on insulin resistance.Source
Wang J, Persuitte G, Olendzki BC, Wedick NM, Zhang Z, Merriam PA, Fang H, Carmody J, Olendzki G-F, Ma Y. Dietary Magnesium Intake Improves Insulin Resistance among Non-Diabetic Individuals with Metabolic Syndrome Participating in a Dietary Trial. Nutrients. 2013; 5(10):3910-3919. doi: 10.3390/nu5103910. Link to article on publisher's siteDOI
10.3390/nu5103910Permanent Link to this Item
http://hdl.handle.net/20.500.14038/30029PubMed ID
24084051Related Resources
Link to Article in PubMedRights
Copyright 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).ae974a485f413a2113503eed53cd6c53
10.3390/nu5103910