A population-based dietary inflammatory index predicts levels of C-reactive protein in the Seasonal Variation of Blood Cholesterol Study (SEASONS)
Department of Medicine, Division of Preventive and Behavioral Medicine; Department of Medicine, Division of Cadiovascular Medicine
Community Health and Preventive Medicine | Dietetics and Clinical Nutrition | Epidemiology
OBJECTIVE: To perform construct validation of the population-based Dietary Inflammatory Index (DII) using dietary data from two different dietary assessments and serum high-sensitivity C-reactive protein (hs-CRP) as the construct validator.
DESIGN: Using data derived from (i) three 24 h dietary recalls (24HR) at baseline and at the end of each subsequent quarter (i.e. up to fifteen over a year) and (ii) a 7 d dietary recall (7DDR) measured at baseline and then quarterly, regression analyses were conducted to test the effect of the DII score on serum hs-CRP as dichotomous (3 mg/l), while controlling for important potential confounders.
SETTING: Existing data from the Seasonal Variation of Blood Cholesterol Study (SEASONS), a longitudinal observational study of healthy participants recruited in Worcester, MA, USA and participants were followed for 1 year.
SUBJECTS: Participants who had at least one hs-CRP measurement over her/his 1-year participation (n 495 for 24HR, n 559 for 7DDR).
RESULTS: Higher DII scores were associated with values of hs-CRP >3 mg/l (OR = 1.08; 95 % CI 1.01, 1.16, P = 0.035 for the 24HR; and OR = 1.10; 95 % CI 1.02, 1.19, P = 0.015 for the 7DDR).
CONCLUSIONS: The population-based DII was associated with interval changes in hs-CRP using both the 24HR and 7DDR. The success of this first-of-a-kind attempt at relating individuals' intakes of inflammation-modulating foods using this refined DII, and the finding that there is virtually no drop-off in predictive capability using a structured questionnaire in comparison to the 24HR standard, sets the stage for use of the DII in a wide variety of other epidemiological and clinical studies.
DOI of Published Version
Nitin Shivappa, Susan E Steck, Thomas G Hurley, James R Hussey, Yunsheng Ma, Ira S Ockene, Fred Tabung and James R Hebert. A population-based dietary inflammatory index predicts levels of C-reactive protein in the Seasonal Variation of Blood Cholesterol Study (SEASONS). Public Health Nutr.2014 Aug;17(8):1825-33. doi: 10.1017/S1368980013002565. Link to article on publisher's site
Public health nutrition
Shivappa N, Steck SE, Hurley TG, Hussey JR, Ma Y, Ockene IS, Tabung F, Hebert JR. (2014). A population-based dietary inflammatory index predicts levels of C-reactive protein in the Seasonal Variation of Blood Cholesterol Study (SEASONS). University of Massachusetts Medical School Faculty Publications. https://doi.org/10.1017/S1368980013002565. Retrieved from https://escholarship.umassmed.edu/faculty_pubs/257