University of Massachusetts Medical School Faculty Publications
Title
NK cells controlling virus-specific T cells: Rheostats for acute vs. persistent infections
UMMS Affiliation
Department of Pathology
Publication Date
2013-01-05
Document Type
Article
Subjects
Acute Disease; Animals; Chronic Disease; Herpesviridae Infections; Humans; Immunity, Humoral; Immunity, Innate; Immunomodulation; Killer Cells, Natural; Lymphocytic Choriomeningitis; Lymphocytic choriomeningitis virus; Mice; Muromegalovirus; Receptors, Natural Killer Cell; T-Lymphocytes
Disciplines
Immunology of Infectious Disease | Immunopathology | Virology
Abstract
Viral infections characteristically induce a cytokine-driven activated natural killer (NK) cell response that precedes an antigen-driven T cell response. These NK cells can restrain some but not all viral infections by attacking virus-infected cells and can thereby provide time for an effective T cell response to mobilize. Recent studies have revealed an additional immunoregulatory role for the NK cells, where they inhibit the size and functionality of the T cell response, regardless of whether the viruses are themselves sensitive to NK cells. This subsequent change in T cell dynamics can alter patterns of immunopathology and persistence and implicates NK cells as rheostat-like regulators of persistent infections.
DOI of Published Version
10.1016/j.virol.2012.10.005
Source
Virology. 2013 Jan 5;435(1):37-45. doi: 10.1016/j.virol.2012.10.005. Link to article on publisher's website
Related Resources
Journal/Book/Conference Title
Virology
PubMed ID
23217614
Repository Citation
Welsh, Raymond M. and Waggoner, Stephen N., "NK cells controlling virus-specific T cells: Rheostats for acute vs. persistent infections" (2013). University of Massachusetts Medical School Faculty Publications. 253.
https://escholarship.umassmed.edu/faculty_pubs/253