University of Massachusetts Medical School Faculty Publications
Title
Releasing the brakes on a chromatin-remodeling enzyme
UMMS Affiliation
Program in Molecular Medicine
Publication Date
2013-1
Document Type
Article
Subjects
Adenosine Triphosphate; Animals; Cell Cycle; Chromatin; *Chromatin Assembly and Disassembly; DNA; DNA Helicases; Histones; Humans; Nuclear Proteins; Nucleosomes; Promoter Regions, Genetic; Transcription, Genetic
Disciplines
Cell Biology | Molecular Biology | Structural Biology
Abstract
Chromatin-remodeling enzymes use the energy from ATP hydrolysis to mobilize, disrupt or change the histone composition of nucleosomes, facilitating nearly every nuclear event. Two recent studies indicate that remodeling enzymes harness the power of an ancient constitutively active DNA translocase and that different remodeling enzymes may use specialized coupling domains that communicate the presence of nucleosomal epitopes to regulate translocase and remodeling activity.
DOI of Published Version
10.1038/nsmb.2482
Source
Nat Struct Mol Biol. 2013 Jan;20(1):5-7. doi: 10.1038/nsmb.2482. Link to article on publisher's site
Related Resources
Journal/Book/Conference Title
Nature structural and molecular biology
PubMed ID
23288358
Repository Citation
Manning BJ, Peterson CL. (2013). Releasing the brakes on a chromatin-remodeling enzyme. University of Massachusetts Medical School Faculty Publications. https://doi.org/10.1038/nsmb.2482. Retrieved from https://escholarship.umassmed.edu/faculty_pubs/241