Chemical exchange saturation transfer effect in blood
Department of Radiology
Magnetic Resonance Imaging; Blood
Diagnosis | Radiology
PURPOSE: In this report, the feasibility of using blood as an agent for Chemical Exchange Saturation Transfer (CEST) effect is investigated.
METHODS: The CEST effect of porcine blood samples was investigated on a 3.0 T MRI scanner using various power levels and on a 14.1 T NMR spectrometer. As a proof-of-concept that CEST can be used to image blood in vivo, the technique was applied in two locations of healthy human volunteers, namely, the femoral artery and the M1-segment of the middle cerebral artery.
RESULTS: The blood sample experiments showed that maximum CEST Magnetization Transfer Ratio asymmetry (MTRasym ) values of approximately 12% were achieved, with likely contributions from multiple blood components. These findings were confirmed during the in vivo experiments where CEST signal of blood was clearly greater than surrounding muscular (2%) and brain tissue (3%).
CONCLUSION: Ex vivo and in vivo results show that blood is a suitable CEST agent that generates sufficient CEST contrast relative to surrounding tissue.
DOI of Published Version
Magn Reson Med. 2013 May 9. doi: 10.1002/mrm.24770. Link to article on publisher's site
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine
Zheng, Shaokuan; van der Bom, Imramsjah M. J.; Zu, Zhongliang; Lin, Guoxing; Zhao, Yansong; and Gounis, Matthew J., "Chemical exchange saturation transfer effect in blood" (2013). University of Massachusetts Medical School Faculty Publications. 24.