Chemical exchange saturation transfer effect in blood
Department of Radiology
Magnetic Resonance Imaging; Blood
Diagnosis | Radiology
PURPOSE: In this report, the feasibility of using blood as an agent for Chemical Exchange Saturation Transfer (CEST) effect is investigated.
METHODS: The CEST effect of porcine blood samples was investigated on a 3.0 T MRI scanner using various power levels and on a 14.1 T NMR spectrometer. As a proof-of-concept that CEST can be used to image blood in vivo, the technique was applied in two locations of healthy human volunteers, namely, the femoral artery and the M1-segment of the middle cerebral artery.
RESULTS: The blood sample experiments showed that maximum CEST Magnetization Transfer Ratio asymmetry (MTRasym ) values of approximately 12% were achieved, with likely contributions from multiple blood components. These findings were confirmed during the in vivo experiments where CEST signal of blood was clearly greater than surrounding muscular (2%) and brain tissue (3%).
CONCLUSION: Ex vivo and in vivo results show that blood is a suitable CEST agent that generates sufficient CEST contrast relative to surrounding tissue.
DOI of Published Version
Magn Reson Med. 2013 May 9. doi: 10.1002/mrm.24770. Link to article on publisher's site
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine
Zheng S, van der Bom IM, Zu Z, Lin G, Zhao Y, Gounis MJ. (2013). Chemical exchange saturation transfer effect in blood. UMass Chan Medical School Faculty Publications. https://doi.org/10.1002/mrm.24770. Retrieved from https://escholarship.umassmed.edu/faculty_pubs/24