UMass Chan Medical School Faculty Publications

UMMS Affiliation

Department of Neurobiology; Graduate School of Biomedical Sciences; Yang Xiang Lab

Publication Date


Document Type



Neuroscience and Neurobiology


Significance: Functional plasticity of the nociceptive circuit is a remarkable feature and is of clinical relevance. As an example, nociceptors lower their threshold upon tissue injury, a process known as allodynia that would facilitate healing by guarding the injured areas. However, long-lasting hypersensitivity could lead to chronic pain, a debilitating disease not effectively treated. Therefore, it is crucial to dissect the mechanisms underlying basal nociception and nociceptive hypersensitivity. In both vertebrate and invertebrate species, conserved transient receptor potential (Trp) channels are the primary transducers of noxious stimuli. Here, we provide a precedent that in Drosophila larvae, heat sensing in the nociception and hypersensitivity states is mediated by distinct heat-sensitive neurons and TrpA1 alternative isoforms.


Drosophila, alternative splicing, nociception, nociceptive hypersensitivity, transient receptor potential (Trp)

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Copyright © 2022 the Author(s). Published by PNAS. This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

DOI of Published Version



Gu P, Wang F, Shang Y, Liu J, Gong J, Xie W, Han J, Xiang Y. Nociception and hypersensitivity involve distinct neurons and molecular transducers in Drosophila. Proc Natl Acad Sci U S A. 2022 Mar 22;119(12):e2113645119. doi: 10.1073/pnas.2113645119. Epub 2022 Mar 16. PMID: 35294287; PMCID: PMC8944580. Link to article on publisher's site

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Link to Article in PubMed

Journal/Book/Conference Title

Proceedings of the National Academy of Sciences of the United States of America

PubMed ID


Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.