UMass Chan Medical School Faculty Publications

Title

Spatial transcriptomic reconstruction of the mouse olfactory glomerular map suggests principles of odor processing

UMMS Affiliation

Program in Molecular Medicine; Program in Bioinformatics and Integrative Biology; Department of Neurobiology; Brudnick Neuropsychiatric Research Institute; Sanderson Center for Optical Imaging; Department of Microbiology and Physiological Systems; Schafer Lab

Publication Date

2022-03-21

Document Type

Article

Disciplines

Neuroscience and Neurobiology

Abstract

The olfactory system's ability to detect and discriminate between the vast array of chemicals present in the environment is critical for an animal's survival. In mammals, the first step of this odor processing is executed by olfactory sensory neurons, which project their axons to a stereotyped location in the olfactory bulb (OB) to form glomeruli. The stereotyped positioning of glomeruli in the OB suggests an importance for this organization in odor perception. However, because the location of only a limited subset of glomeruli has been determined, it has been challenging to determine the relationship between glomerular location and odor discrimination. Using a combination of single-cell RNA sequencing, spatial transcriptomics and machine learning, we have generated a map of most glomerular positions in the mouse OB. These observations significantly extend earlier studies and suggest an overall organizational principle in the OB that may be used by the brain to assist in odor decoding.

DOI of Published Version

10.1038/s41593-022-01030-8

Source

Wang IH, Murray E, Andrews G, Jiang HC, Park SJ, Donnard E, Durán-Laforet V, Bear DM, Faust TE, Garber M, Baer CE, Schafer DP, Weng Z, Chen F, Macosko EZ, Greer PL. Spatial transcriptomic reconstruction of the mouse olfactory glomerular map suggests principles of odor processing. Nat Neurosci. 2022 Apr;25(4):484-492. doi: 10.1038/s41593-022-01030-8. Epub 2022 Mar 21. PMID: 35314823. Link to article on publisher's site

Comments

Full author list omitted for brevity. For the full list of authors, see article.

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Nature neuroscience

PubMed ID

35314823

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