UMass Chan Medical School Faculty Publications

Title

Cerebrospinal fluid xanthochromia in newborns is related to maternal labor before delivery

UMMS Affiliation

Department of Pediatrics, Division of Pediatric Pulmonology

Publication Date

2007-11-01

Document Type

Article

Disciplines

Maternal and Child Health | Pediatrics

Abstract

OBJECTIVE: The purpose of this work was to investigate whether xanthochromia in newborns is related to maternal labor before delivery.

METHODS: We reviewed the medical charts of all of the infants < or = 30 days of age who had a lumbar puncture performed in a single pediatric emergency department between 2003 and 2005. Xanthochromia was detected by the hospital laboratory using the qualitative visual inspection method. We used logistic regression to determine the relationship between maternal labor before birth and the presence of cerebrospinal fluid xanthochromia, adjusting for factors known to be associated with xanthochromia.

RESULTS: Of the 478 newborns who had a lumbar puncture performed during the study period, 134 (28%) had xanthochromia. Of the 449 infants with delivery method recorded in the medical chart, 332 (74%) were born via vaginal delivery, 24 (5%) via cesarean section after maternal labor, and 93 (21%) via cesarean section without maternal labor. After excluding patients with hyperbilirubinemia (total bilirubin > or = 15 mg/dL) and adjusting for factors known to be associated with xanthochromia (cerebrospinal fluid red blood cells > or = 20,000 cells per mL and cerebrospinal fluid protein > or = 150 mg/dL), infants born after maternal labor had a higher rate of cerebrospinal fluid xanthochromia than infants born without any labor.

CONCLUSIONS: Xanthochromia is a common finding in the cerebrospinal fluid of newborns and is associated with maternal labor preceding delivery.

Keywords

cerebrospinal fluid, labor, xanthochromia, cerebrospinal fluid proteins, delivery method

DOI of Published Version

10.1542/peds.2007-0681

Source

Nigrovic LE, Trivedi M, Edlow JA, Neuman MI. Cerebrospinal fluid xanthochromia in newborns is related to maternal labor before delivery. Pediatrics. 2007 Nov;120(5):e1212-6. doi: 10.1542/peds.2007-0681. Epub 2007 Oct 8. PMID: 17923536. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Pediatrics

PubMed ID

17923536

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