Longitudinal analysis of SARS-CoV-2 vaccine breakthrough infections reveal limited infectious virus shedding and restricted tissue distribution [preprint]
Authors
Ke, RuianOwens, Alyssa N.
Broach, John
Barton, Bruce A.
Lazar, Peter
McManus, David D.
Brooke, Christopher B.
UMass Chan Affiliations
Department of Medicine, Division of Cardiovascular MedicineDivision of Biostatistics and Health Services Research, Department of Population and Quantitative Health Sciences
Department of Emergency Medicine
UMass Center for Clinical and Translational Research
Document Type
PreprintPublication Date
2021-09-02Keywords
Infectious DiseasesSARS-CoV-2
vaccination
breakthrough infections
COVID-19
UMCCTS funding
Immunology of Infectious Disease
Immunopathology
Immunoprophylaxis and Therapy
Infectious Disease
Microbiology
Virus Diseases
Metadata
Show full item recordAbstract
The global effort to vaccinate people against SARS-CoV-2 in the midst of an ongoing pandemic has raised questions about the nature of vaccine breakthrough infections and the potential for vaccinated individuals to transmit the virus. These questions have become even more urgent as new variants of concern with enhanced transmissibility, such as Delta, continue to emerge. To shed light on how vaccine breakthrough infections compare with infections in immunologically naive individuals, we examined viral dynamics and infectious virus shedding through daily longitudinal sampling in a small cohort of adults infected with SARS-CoV-2 at varying stages of vaccination. The durations of both infectious virus shedding and symptoms were significantly reduced in vaccinated individuals compared with unvaccinated individuals. We also observed that breakthrough infections are associated with strong tissue compartmentalization and are only detectable in saliva in some cases. These data indicate that vaccination shortens the duration of time of high transmission potential, minimizes symptom duration, and may restrict tissue dissemination.Source
Ke R, Martinez PP, Smith RL, Gibson LL, Achenbach CJ, McFall S, Qi C, Jacob J, Dembele E, Bundy C, Simons LM, Ozer EA, Hultquist JF, Lorenzo-Redondo R, Opdycke AK, Hawkins C, Murphy RL, Mirza A, Conte M, Gallagher N, Luo CH, Jarrett J, Conte A, Zhou R, Farjo M, Rendon G, Fields CJ, Wang L, Fredrickson R, Baughman ME, Chiu KK, Choi H, Scardina KR, Owens AN, Broach J, Barton B, Lazar P, Robinson ML, Mostafa HH, Manabe YC, Pekosz A, McManus DD, Brooke CB. Longitudinal analysis of SARS-CoV-2 vaccine breakthrough infections reveal limited infectious virus shedding and restricted tissue distribution. medRxiv [Preprint]. 2021 Sep 2:2021.08.30.21262701. doi: 10.1101/2021.08.30.21262701. PMID: 34494028; PMCID: PMC8423226. Link to article on publisher's site
DOI
10.1101/2021.08.30.21262701Permanent Link to this Item
http://hdl.handle.net/20.500.14038/29960PubMed ID
34494028Notes
This article is a preprint. Preprints are preliminary reports of work that have not been certified by peer review.
Full author list omitted for brevity. For the full list of authors, see article.