University of Massachusetts Medical School Faculty Publications
UMMS Affiliation
Department of Surgery; Department of Radiation Oncology; Department of Medicine
Publication Date
2013-02-22
Document Type
Article
Disciplines
Oncology | Radiology | Surgery
Abstract
Purpose: Chest wall pain and discomfort has been recognized as a significant late effect of radiation therapy in historical and modern treatment models. Stereotactic Body Radiotherapy (SBRT) is becoming an important treatment tool in oncology care for patients with intrathoracic lesions. For lesions in close approximation to the chest wall with motion management, SBRT techniques can deliver high dose to the chest wall. As an unintended target of consequence, there is possibility of imposing significant chest wall pain and discomfort as a late effect of therapy. The purpose of this paper is to evaluate the potential role of Volume Modulated Arc Therapy (VMAT) technologies in decreasing chest wall dose in SBRT treatment of pulmonary lesions in close approximation to the chest wall.Materials and
Methods: Ten patients with pulmonary lesions of various sizes and tomography in close approximation to the chest wall were selected for retrospective review. All volumes including tumor target, chest wall, ribs, and lung were contoured with maximal intensity projection maps and four-dimensional computer tomography planning. Radiation therapy planning consisted of static techniques including Intensity Modulated Radiation Therapy compared to VMAT therapy to a dose of 60 Gy in 12 Gy fraction dose. Dose volume histogram to rib, chest wall, and lung were compared between plans with statistical analysis.
Results: In all patients, dose and volume were improved to ribs and chest wall using VMAT technologies compared to static field techniques. On average, volume receiving 30 Gy to the chest wall was improved by 74%; the ribs by 60%. In only one patient did the VMAT treatment technique increase pulmonary volume receiving 20 Gy (V20).
Conclusions: VMAT technology has potential of limiting radiation dose to sensitive chest wall regions in patients with lesions in close approximation to this structure. This would also have potential value to lesions treated with SBRT in other body regions where targets abut critical structures.
Keywords
Volume Modulated Arc Therapy, Chest wall, Intrathoracic lesions, Radiation therapy, Stereotactic body radiotherapy
Rights and Permissions
Copyright 2013 Ding, Lo, Kadish, Goff, Pieters, Graeber, Uy, Quadri, Moser, Martin, Day and FitzGerald. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
DOI of Published Version
10.3389/fonc.2013.00012
Source
Ding L, Lo YC, Kadish S, Goff D, Pieters RS, Graeber G, Uy K, Quadri S, Moser R, Martin K, Day J, Fitzgerald TJ. Volume Modulated Arc Therapy (VMAT) for pulmonary Stereotactic Body Radiotherapy (SBRT) in patients with lesions in close approximation to the chest wall. Front Oncol. 2013;3:12. doi:10.3389/fonc.2013.00012. Link to article on publisher's site
Related Resources
Journal/Book/Conference Title
Frontiers in oncology
PubMed ID
23440876
Repository Citation
Ding, Linda; Lo, Yuan-Chyuan; Kadish, Sidney P.; Goff, David C. Jr.; Pieters, Richard S.; Graeber, Geoffrey; Uy, Karl; Quadri, Syed; Moser, Richard P.; Martin, Kevin; Day, John; and Fitzgerald, Thomas J., "Volume Modulated Arc Therapy (VMAT) for pulmonary Stereotactic Body Radiotherapy (SBRT) in patients with lesions in close approximation to the chest wall" (2013). University of Massachusetts Medical School Faculty Publications. 216.
https://escholarship.umassmed.edu/faculty_pubs/216