IL-6 boosts synaptogenesis STAT!
Department of Neurobiology; Schafer Lab
Amino Acids, Peptides, and Proteins | Developmental Neuroscience | Immunity | Molecular and Cellular Neuroscience
Maternal infection during pregnancy increases the offspring's risk of developing neurodevelopmental disorders. While IL-6 is involved, the mechanism by which IL-6 and other cytokines affect developing neural circuits is unknown. In this issue of Immunity, Mirabella et al. (2021) show that the pro-inflammatory cytokine IL-6 specifically increases synaptogenesis in immature excitatory neurons through downstream neuronal STAT3-dependent transcriptional regulation of Rgs4.
DOI of Published Version
Faust TE, Schafer DP. IL-6 boosts synaptogenesis STAT! Immunity. 2021 Nov 9;54(11):2444-2446. doi: 10.1016/j.immuni.2021.10.010. PMID: 34758335. Link to article on publisher's site
Faust TE, Schafer DP. (2021). IL-6 boosts synaptogenesis STAT!. University of Massachusetts Medical School Faculty Publications. https://doi.org/10.1016/j.immuni.2021.10.010. Retrieved from https://escholarship.umassmed.edu/faculty_pubs/2128