UMass Chan Medical School Faculty Publications

Title

IL-6 boosts synaptogenesis STAT!

UMMS Affiliation

Department of Neurobiology; Schafer Lab

Publication Date

2021-11-09

Document Type

Article

Disciplines

Amino Acids, Peptides, and Proteins | Developmental Neuroscience | Immunity | Molecular and Cellular Neuroscience

Abstract

Maternal infection during pregnancy increases the offspring's risk of developing neurodevelopmental disorders. While IL-6 is involved, the mechanism by which IL-6 and other cytokines affect developing neural circuits is unknown. In this issue of Immunity, Mirabella et al. (2021) show that the pro-inflammatory cytokine IL-6 specifically increases synaptogenesis in immature excitatory neurons through downstream neuronal STAT3-dependent transcriptional regulation of Rgs4.

DOI of Published Version

10.1016/j.immuni.2021.10.010

Source

Faust TE, Schafer DP. IL-6 boosts synaptogenesis STAT! Immunity. 2021 Nov 9;54(11):2444-2446. doi: 10.1016/j.immuni.2021.10.010. PMID: 34758335. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Immunity

PubMed ID

34758335

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