UMass Chan Medical School Faculty Publications

UMMS Affiliation

Program in Bioinformatics and Integrative Biology; Program in Molecular Medicine

Publication Date

2021-09-06

Document Type

Article

Disciplines

Ecology and Evolutionary Biology | Integrative Biology | Veterinary Medicine

Abstract

The ancient partnership between people and dogs is struggling to meet modern day needs, with demand exceeding our capacity to safely breed high-performing and healthy dogs. New statistical genetic approaches and genomic technology have the potential to revolutionize dog breeding, by transitioning from problematic phenotypic selection to methods that can preserve genetic diversity while increasing the proportion of successful dogs. To fully utilize this technology will require ultra large datasets, with hundreds of thousands of dogs. Today, dog breeders struggle to apply even the tools available now, stymied by the need for sophisticated data storage infrastructure and expertise in statistical genetics. Here, we review recent advances in animal breeding, and how a new approach to dog breeding would address the needs of working dog breeders today while also providing them with a path to realizing the next generation of technology. We provide a step-by-step guide for dog breeders to start implementing estimated breeding value selection in their programs now, and we describe how genotyping and DNA sequencing data, as it becomes more widely available, can be integrated into this approach. Finally, we call for data sharing among dog breeding programs as a path to achieving a future that can benefit all dogs, and their human partners too.

Keywords

EBV, behavior, dog breeding, genetic selection, genomics, guide dog, heritability, working dog

Rights and Permissions

Copyright © 2021 Chen, Zimmermann, Hekman, Lord, Logan, Russenberger, Leighton and Karlsson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

DOI of Published Version

10.3389/fvets.2021.662429

Source

Chen FL, Zimmermann M, Hekman JP, Lord KA, Logan B, Russenberger J, Leighton EA, Karlsson EK. Advancing Genetic Selection and Behavioral Genomics of Working Dogs Through Collaborative Science. Front Vet Sci. 2021 Sep 6;8:662429. doi: 10.3389/fvets.2021.662429. PMID: 34552971; PMCID: PMC8450581. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Frontiers in veterinary science

PubMed ID

34552971

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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