Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma
Department of Emergency Medicine; UMMS - Baystate Regional Campus
Cognitive Neuroscience | Psychiatry | Psychiatry and Psychology | Trauma
OBJECTIVE: Major negative life events, such as trauma exposure, can play a key role in igniting or exacerbating psychopathology. However, few disorders are diagnosed with respect to precipitating events, and the role of these events in the unfolding of new psychopathology is not well understood. The authors conducted a multisite transdiagnostic longitudinal study of trauma exposure and related mental health outcomes to identify neurobiological predictors of risk, resilience, and different symptom presentations.
METHODS: A total of 146 participants (discovery cohort: N=69; internal replication cohort: N=77) were recruited from emergency departments within 72 hours of a trauma and followed for the next 6 months with a survey, MRI, and physiological assessments.
RESULTS: Task-based functional MRI 2 weeks after a motor vehicle collision identified four clusters of individuals based on profiles of neural activity reflecting threat reactivity, reward reactivity, and inhibitory engagement. Three clusters were replicated in an independent sample with a variety of trauma types. The clusters showed different longitudinal patterns of posttrauma symptoms.
CONCLUSIONS: These findings provide a novel characterization of heterogeneous stress responses shortly after trauma exposure, identifying potential neuroimaging-based biotypes of trauma resilience and psychopathology.
Biological Markers, Cognitive Neuroscience, Neuroimaging, Posttraumatic Stress Disorder (PTSD), Stress
DOI of Published Version
Stevens JS, Harnett NG, Lebois LAM, van Rooij SJH, Ely TD, Roeckner A, Vincent N, Beaudoin FL, An X, Zeng D, Neylan TC, Clifford GD, Linnstaedt SD, Germine LT, Rauch SL, Lewandowski C, Storrow AB, Hendry PL, Sheikh S, Musey PI Jr, Haran JP, Jones CW, Punches BE, Lyons MS, Kurz MC, McGrath ME, Pascual JL, Datner EM, Chang AM, Pearson C, Peak DA, Domeier RM, O'Neil BJ, Rathlev NK, Sanchez LD, Pietrzak RH, Joormann J, Barch DM, Pizzagalli DA, Sheridan JF, Luna B, Harte SE, Elliott JM, Murty VP, Jovanovic T, Bruce SE, House SL, Kessler RC, Koenen KC, McLean SA, Ressler KJ. Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma. Am J Psychiatry. 2021 Nov;178(11):1037-1049. doi: 10.1176/appi.ajp.2021.20101526. Epub 2021 Oct 14. PMID: 34645277. Link to article on publisher's site
The American journal of psychiatry
Stevens JS, Haran JP, Rathlev N. (2021). Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma. University of Massachusetts Medical School Faculty Publications. https://doi.org/10.1176/appi.ajp.2021.20101526. Retrieved from https://escholarship.umassmed.edu/faculty_pubs/2111