University of Massachusetts Medical School Faculty Publications
Title
Surface-grafted zwitterionic polymers improve the efficacy of a single antibiotic injection in suppressing S. aureus periprosthetic infections
UMMS Affiliation
Department of Orthopedics and Physical Rehabilitation
Publication Date
2021-09-02
Document Type
Article
Disciplines
Bacterial Infections and Mycoses | Biomaterials | Biomedical Devices and Instrumentation | Materials Chemistry | Orthopedics
Abstract
Implant-associated bacterial infections are difficult to treat due to the tendency of biofilm formation on implant surfaces, which protects embedded pathogens from host defense and impedes antibiotic penetration, rendering systemic antibiotic injections ineffective. Here, we test the hypothesis that implant coatings that reduce bacterial colonization would make planktonic bacteria within the periprosthetic environment more susceptible to conventional systemic antibiotic treatment. We covalently grafted zwitterionic polymer brushes poly(sulfobetaine methacryate) from Ti6Al4V surface to increase the substrate surface hydrophilicity and reduce staphylococcus aureus (S. aureus) adhesion. Using a mouse femoral intramedullary (IM) canal infection model, we showed that the anti-fouling coating applied to Ti6Al4V IM implants, when combined with a single vancomycin systemic injection, significantly suppressed both bacterial colonization on implant surfaces and the periprosthetic infections, outperforming either treatment alone. This work supports the hypothesis that grafting anti-fouling polymers to implant surfaces improves the efficacy of systemic antibiotic injections to combat periprosthetic infections.
Keywords
Staphylococcus aureus, anti-fouling, bacterial colonization on surfaces, osteomyelitis, periprosthetic infections, planktonic bacteria, zwitterionic polymer brush
DOI of Published Version
10.1021/acsabm.0c00600
Source
Zhang B, Skelly JD, Braun BM, Ayers DC, Song J. Surface-grafted zwitterionic polymers improve the efficacy of a single antibiotic injection in suppressing S. aureus periprosthetic infections. ACS Appl Bio Mater. 2020 Sep 21;3(9):5896-5904. doi: 10.1021/acsabm.0c00600. Epub 2020 Sep 2. PMID: 34368642; PMCID: PMC8340630. Link to article on publisher's site
Related Resources
Journal/Book/Conference Title
ACS applied bio materials
PubMed ID
34368642
Repository Citation
Zhang B, Skelly JD, Braun BM, Ayers DC, Song J. (2021). Surface-grafted zwitterionic polymers improve the efficacy of a single antibiotic injection in suppressing S. aureus periprosthetic infections. University of Massachusetts Medical School Faculty Publications. https://doi.org/10.1021/acsabm.0c00600. Retrieved from https://escholarship.umassmed.edu/faculty_pubs/2108