Program in Molecular Medicine; Program in Bioinformatics and Integrative Biology
Genetics and Genomics | Medical Genetics | Mental and Social Health | Neuroscience and Neurobiology | Psychiatry | Psychiatry and Psychology
Obsessive-compulsive disorder (OCD) is a heritable disorder, but no definitive, replicated OCD susceptibility loci have yet been identified by any genome-wide association study (GWAS). Here, we report results from a GWAS in the largest OCD case-control sample (N = 14,140 OCD cases and N = 562,117 controls) to date. We explored the genetic architecture of OCD, including its genetic relationships to other psychiatric and non-psychiatric phenotypes. In the GWAS analysis, we identified one SNP associated with OCD at a genome-wide significant level. Subsequent gene-based analyses identified additional two genes as potentially implicated in OCD pathogenesis. All SNPs combined explained 16% of the heritability of OCD. We show sub-stantial positive genetic correlations between OCD and a range of psychiatric disorders, including anxiety disorders, anorexia nervosa, and major depression. We thus for the first time provide evidence of a genome-wide locus implicated in OCD and strengthen previous literature suggesting a polygenic nature of this disorder.
Psychiatry and Clinical Psychology, Obsessive-compulsive disorder, OCD
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DOI of Published Version
medRxiv 2021.10.13.21261078; doi: https://doi.org/10.1101/2021.10.13.21261078. Link to preprint on medRxiv.
Strom NI, Karlsson EK, Mattheisen M. (2021). Genome-wide association study identifies new locus associated with OCD [preprint]. University of Massachusetts Medical School Faculty Publications. https://doi.org/10.1101/2021.10.13.21261078. Retrieved from https://escholarship.umassmed.edu/faculty_pubs/2106
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