University of Massachusetts Medical School Faculty Publications
UMMS Affiliation
Program in Molecular Medicine; Program in Bioinformatics and Integrative Biology
Publication Date
2021-10-23
Document Type
Article Preprint
Disciplines
Genetics and Genomics | Medical Genetics | Mental and Social Health | Neuroscience and Neurobiology | Psychiatry | Psychiatry and Psychology
Abstract
Obsessive-compulsive disorder (OCD) is a heritable disorder, but no definitive, replicated OCD susceptibility loci have yet been identified by any genome-wide association study (GWAS). Here, we report results from a GWAS in the largest OCD case-control sample (N = 14,140 OCD cases and N = 562,117 controls) to date. We explored the genetic architecture of OCD, including its genetic relationships to other psychiatric and non-psychiatric phenotypes. In the GWAS analysis, we identified one SNP associated with OCD at a genome-wide significant level. Subsequent gene-based analyses identified additional two genes as potentially implicated in OCD pathogenesis. All SNPs combined explained 16% of the heritability of OCD. We show sub-stantial positive genetic correlations between OCD and a range of psychiatric disorders, including anxiety disorders, anorexia nervosa, and major depression. We thus for the first time provide evidence of a genome-wide locus implicated in OCD and strengthen previous literature suggesting a polygenic nature of this disorder.
Keywords
Psychiatry and Clinical Psychology, Obsessive-compulsive disorder, OCD
Rights and Permissions
The copyright holder for this preprint is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
DOI of Published Version
10.1101/2021.10.13.21261078
Source
medRxiv 2021.10.13.21261078; doi: https://doi.org/10.1101/2021.10.13.21261078. Link to preprint on medRxiv.
Journal/Book/Conference Title
medRxiv
Repository Citation
Strom NI, Karlsson EK, Mattheisen M. (2021). Genome-wide association study identifies new locus associated with OCD [preprint]. University of Massachusetts Medical School Faculty Publications. https://doi.org/10.1101/2021.10.13.21261078. Retrieved from https://escholarship.umassmed.edu/faculty_pubs/2106
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Included in
Genetics and Genomics Commons, Medical Genetics Commons, Mental and Social Health Commons, Neuroscience and Neurobiology Commons, Psychiatry Commons, Psychiatry and Psychology Commons
Comments
This article is a preprint. Preprints are preliminary reports of work that have not been certified by peer review.
Full author list omitted for brevity. For the full list of authors, see article.