University of Massachusetts Medical School Faculty Publications
UMMS Affiliation
Program in Bioinformatics and Integrative Biology
Publication Date
2021-08-09
Document Type
Article Preprint
Disciplines
Disease Modeling | Genetics and Genomics | Veterinary Medicine
Abstract
The current feline genotyping array of 63k single nucleotide polymorphisms has proven its utility within breeds, and its use has led to the identification of variants associated with Mendelian traits in purebred cats. However, compared to single gene disorders, association studies of complex diseases, especially with the inclusion of random bred cats with relatively low linkage disequilibrium, require a denser genotyping array and an increased sample size to provide statistically significant associations. Here, we undertook a multi-breed study of 1,122 cats, most of which were admitted and phenotyped for nine common complex feline diseases at the Cornell University Hospital for Animals. Using a proprietary 340k single nucleotide polymorphism mapping array, we identified significant genome-wide associations with hyperthyroidism, diabetes mellitus, and eosinophilic keratoconjunctivitis. These results provide genomic locations for variant discovery and candidate gene screening for these important complex feline diseases, which are relevant not only to feline health, but also to the development of disease models for comparative studies.
Keywords
Genetics, genotyping, phenotyping, disease modeling, feline diseases, cats
Rights and Permissions
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
DOI of Published Version
10.1101/2021.08.09.455727
Source
bioRxiv 2021.08.09.455727; doi: https://doi.org/10.1101/2021.08.09.455727. Link to preprint on bioRxiv.
Journal/Book/Conference Title
bioRxiv
Repository Citation
Hernandez I, Hayward JJ, White ME. (2021). Complex feline disease mapping using a dense genotyping array [preprint]. University of Massachusetts Medical School Faculty Publications. https://doi.org/10.1101/2021.08.09.455727. Retrieved from https://escholarship.umassmed.edu/faculty_pubs/2085
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Comments
This article is a preprint. Preprints are preliminary reports of work that have not been certified by peer review.
Full author list omitted for brevity. For the full list of authors, see article.