University of Massachusetts Medical School Faculty Publications
UMMS Affiliation
Wellstone Muscular Dystrophy Program; Department of Neurology; Emerson Lab
Publication Date
2021-06-22
Document Type
Article
Disciplines
Cellular and Molecular Physiology | Congenital, Hereditary, and Neonatal Diseases and Abnormalities | Enzymes and Coenzymes | Musculoskeletal Diseases | Musculoskeletal, Neural, and Ocular Physiology | Nervous System Diseases | Therapeutics
Abstract
p38 MAPKs play a central role in orchestrating the cellular response to stress and inflammation and in the regulation of myogenesis. Potent inhibitors of p38 MAPKs have been pursued as potential therapies for several disease indications due to their antiinflammatory properties, although none have been approved to date. Here, we provide a brief overview of p38 MAPKs, including their role in regulating myogenesis and their association with disease progression. Finally, we discuss targeting p38 MAPKs as a therapeutic approach for treating facioscapulohumeral muscular dystrophy and other muscular dystrophies by addressing multiple pathological mechanisms in skeletal muscle.
Keywords
Mitogen-activated protein kinases, p38 MAPKs, myogenesis, skeletal muscle, facioscapulohumeral muscular dystrophy
Rights and Permissions
Copyright © 2021 Brennan et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
DOI of Published Version
10.1172/jci.insight.149915
Source
Brennan CM, Emerson CP Jr, Owens J, Christoforou N. p38 MAPKs - roles in skeletal muscle physiology, disease mechanisms, and as potential therapeutic targets. JCI Insight. 2021 Jun 22;6(12):e149915. doi: 10.1172/jci.insight.149915. PMID: 34156029; PMCID: PMC8262482. Link to article on publisher's site
Related Resources
Journal/Book/Conference Title
JCI insight
PubMed ID
34156029
Repository Citation
Brennan CM, Emerson CP, Owens J, Christoforou N. (2021). p38 MAPKs - roles in skeletal muscle physiology, disease mechanisms, and as potential therapeutic targets. University of Massachusetts Medical School Faculty Publications. https://doi.org/10.1172/jci.insight.149915. Retrieved from https://escholarship.umassmed.edu/faculty_pubs/2062
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Included in
Cellular and Molecular Physiology Commons, Congenital, Hereditary, and Neonatal Diseases and Abnormalities Commons, Enzymes and Coenzymes Commons, Musculoskeletal Diseases Commons, Musculoskeletal, Neural, and Ocular Physiology Commons, Nervous System Diseases Commons, Therapeutics Commons