University of Massachusetts Medical School Faculty Publications

Title

The Nursing Home Older Adult Gut Microbiome Composition Shows Time-dependent Dysbiosis and is Influenced by Medication Exposures, Age, Environment, and Frailty

UMMS Affiliation

Department of Emergency Medicine; Department of Microbiology and Physiological Systems; Program in Microbiome Dynamics; Graduate School of Biomedical Sciences

Publication Date

2021-06-14

Document Type

Article

Disciplines

Digestive System | Environmental Public Health | Geriatrics | Medical Microbiology | Pathological Conditions, Signs and Symptoms

Abstract

Older adults in nursing homes (NHs) have increased frailty, medication, and antimicrobial exposures, all factors that are known to affect the composition of gut microbiota. Our objective was to define which factors have the greatest association with the NH resident gut microbiota, explore patterns of dysbiosis and compositional changes in gut microbiota over time in this environment. We collected serial stool samples from NH residents. Residents were assessed using the Mini Nutritional Assessment tool and Clinical Frailty Scale. Bacterial composition of resident stool samples was determined by metagenomic sequencing. We used mixed-effect random forest modeling to identify clinical covariates that associate with microbiota. We enrolled and followed 166 residents from 5 NHs collecting 512 stool samples and following 15 residents for > 1 year. Medications, particularly psychoactive and anti-hypertensive medications, had the greatest effect on the microbiota. Age and frailty also contributed, and were associated with increased and decreased diversity, respectively. The microbiota of residents who had lived in the NH for > 1 year were enriched in inflammatory and pathogenic species and reduced in anti-inflammatory and symbiotic species. We observed intra-individual stability of the microbiome among older adults who had lived in the NH already for > 1 year followed with sample collections 1 year apart. Older adult NH gut microbiome is heavily influenced by medications, age, and frailty. This microbiome is influenced by length of NH residence with dysbiosis becoming evident at 12 months, however after this point there is demonstrated relative stability over time.

Keywords

Medications, antibiotics, frailty, gut microbiome, nursing home, residents

DOI of Published Version

10.1093/gerona/glab167

Source

Haran JP, Zeamer A, Ward DV, Dutta P, Bucci V, McCormick BA. The Nursing Home Older Adult Gut Microbiome Composition Shows Time-dependent Dysbiosis and is Influenced by Medication Exposures, Age, Environment, and Frailty. J Gerontol A Biol Sci Med Sci. 2021 Jun 14:glab167. doi: 10.1093/gerona/glab167. Epub ahead of print. PMID: 34125200. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

The journals of gerontology. Series A, Biological sciences and medical sciences

PubMed ID

34125200

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