UMass Chan Medical School Faculty Publications
Title
Chemical biology of protein citrullination by the protein A arginine deiminases
UMMS Affiliation
Department of Biochemistry and Molecular Pharmacology; Program in Chemical Biology; Thompson Lab
Publication Date
2021-03-03
Document Type
Article
Disciplines
Amino Acids, Peptides, and Proteins | Biochemistry | Enzymes and Coenzymes | Medicinal-Pharmaceutical Chemistry
Abstract
Citrullination is a post-translational modification (PTM) that converts peptidyl-arginine into peptidyl-citrulline; citrullination is catalyzed by the protein arginine deiminases (PADs). This PTM is associated with several physiological processes, including the epigenetic regulation of gene expression, neutrophil extracellular trap formation, and DNA-damage induced apoptosis. Notably, aberrant protein citrullination is relevant to several autoimmune and neurodegenerative diseases and certain forms of cancer. As such, the PADs are promising therapeutic targets. In this review, we discuss recent advances in the development of PAD inhibitors and activity-based probes, the development and use of citrulline-specific probes in chemoproteomic applications, and methods to site-specifically incorporate citrulline into proteins.
Keywords
Activity-based protein profiling, Autocitrullination, Citrulline incorporation, Inhibitor, Post-translational modifications, Protein arginine deiminase (PAD)
DOI of Published Version
10.1016/j.cbpa.2021.01.010
Source
Mondal S, Thompson PR. Chemical biology of protein citrullination by the protein A arginine deiminases. Curr Opin Chem Biol. 2021 Mar 3;63:19-27. doi: 10.1016/j.cbpa.2021.01.010. Epub ahead of print. PMID: 33676233. Link to article on publisher's site
Related Resources
Journal/Book/Conference Title
Current opinion in chemical biology
PubMed ID
33676233
Repository Citation
Mondal S, Thompson PR. (2021). Chemical biology of protein citrullination by the protein A arginine deiminases. UMass Chan Medical School Faculty Publications. https://doi.org/10.1016/j.cbpa.2021.01.010. Retrieved from https://escholarship.umassmed.edu/faculty_pubs/1997