University of Massachusetts Medical School Faculty Publications

Title

Diversity and Function of Glial Cell Types in Multiple Sclerosis

UMMS Affiliation

Department of Neurobiology; Brudnik Neuropsychiatric Research Institute; Schafer Lab

Publication Date

2021-03-01

Document Type

Article

Disciplines

Immune System Diseases | Immunity | Immunopathology | Molecular and Cellular Neuroscience | Nervous System Diseases

Abstract

Glial subtype diversity is an emerging topic in neurobiology and immune-mediated neurological diseases such as multiple sclerosis (MS). We discuss recent conceptual and technological advances that allow a better understanding of the transcriptomic and functional heterogeneity of oligodendrocytes (OLs), astrocytes, and microglial cells under inflammatory-demyelinating conditions. Recent single cell transcriptomic studies suggest the occurrence of novel homeostatic and reactive glial subtypes and provide insight into the molecular events during disease progression. Multiplexed RNA in situ hybridization has enabled 'mapping back' dysregulated gene expression to glial subtypes within the MS lesion microenvironment. These findings suggest novel homeostatic and reactive glial-cell-type functions both in immune-related processes and neuroprotection relevant to understanding the pathology of MS.

Keywords

astrocytes, microglia, multiple sclerosis, neuroinflammation, oligodendrocytes, transcriptomics

DOI of Published Version

10.1016/j.it.2021.01.005

Source

Schirmer L, Schafer DP, Bartels T, Rowitch DH, Calabresi PA. Diversity and Function of Glial Cell Types in Multiple Sclerosis. Trends Immunol. 2021 Mar;42(3):228-247. doi: 10.1016/j.it.2021.01.005. Epub 2021 Feb 13. PMID: 33593693; PMCID: PMC7914214. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Trends in immunology

PubMed ID

33593693

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