UMass Chan Medical School Faculty Publications
UMMS Affiliation
Program in Bioinformatics and Integrative Biology; Graduate School of Biomedical Sciences
Publication Date
2021-02-18
Document Type
Article Preprint
Disciplines
Bioinformatics | Cancer Biology | Molecular Biology
Abstract
The YAP and TAZ paralogues are transcriptional co-activators recruited to target sites, primarily by TEAD proteins. Here, we show that YAP and TAZ are also recruited by JUNB and STAT3, key factors that mediate an epigenetic switch linking inflammation to cellular transformation. YAP and TAZ directly interact with JUNB and STAT3 via a WW domain important for transformation, co-occupy many target sites in vivo via AP-1 and (to a lesser extent) STAT3 sequence motifs, and stimulate transcriptional activation by AP-1 proteins. A few target sites are YAP- or TAZ-specific, and they are associated with different sequence motifs and gene classes. YAP/TAZ, JUNB, and STAT3 directly regulate a common set of target genes that overlap, but are distinct from, those regulated by YAP/TAZ and TEADs. The set of genes regulated by YAP/TAZ, STAT3, and JUNB is associated with poor survival in breast cancer patients with the triple-negative form of the disease.
Keywords
Molecular Biology, YAP/TAZ, TEADs, STAT3, JUNB
Rights and Permissions
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
DOI of Published Version
10.1101/2021.02.18.431832
Source
bioRxiv 2021.02.18.431832; doi: https://doi.org/10.1101/2021.02.18.431832. Link to preprint on bioRxiv.
Journal/Book/Conference Title
bioRxiv
Repository Citation
He L, Pratt HE, Wei F, Gao M, Weng Z, Struhl K. (2021). YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation [preprint]. UMass Chan Medical School Faculty Publications. https://doi.org/10.1101/2021.02.18.431832. Retrieved from https://escholarship.umassmed.edu/faculty_pubs/1931
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Comments
This article is a preprint. Preprints are preliminary reports of work that have not been certified by peer review.