Immunology and Microbiology Program, Graduate School of Biomedical Sciences; Department of Microbiology and Physiological Systems
Bacteria | Bacterial Infections and Mycoses | Immunity | Immunology of Infectious Disease | Immunoprophylaxis and Therapy | Microbiology
CD4 T cells are essential for immunity to tuberculosis because they produce cytokines including interferon-γ. Whether CD4 T cells act as “helper” cells to promote optimal CD8 T cell responses during Mycobacterium tuberculosis is unknown. Using two independent models, we show that CD4 T cell help enhances CD8 effector functions and prevents CD8 T cell exhaustion. We demonstrate synergy between CD4 and CD8 T cells in promoting the survival of infected mice. Purified helped, but not helpless, CD8 T cells efficiently restrict intracellular bacterial growth in vitro. Thus, CD4 T cell help plays an essential role in generating protective CD8 T cell responses against M. tuberculosis infection in vitro and in vivo. We infer vaccines that elicit both CD4 and CD8 T cells are more likely to be successful than vaccines that elicit only CD4 or CD8 T cells.
Immunology, immunity, tuberculosis, cytokines, CD4 T cells, CD8 T cells
Rights and Permissions
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
DOI of Published Version
bioRxiv 2021.02.23.432461; doi: https://doi.org/10.1101/2021.02.23.432461. Link to preprint on bioRxiv.
Lu Y, Barreira-Silva P, Boyce S, Powers J, Cavallo K, Behar SM. (2021). CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection [preprint]. University of Massachusetts Medical School Faculty Publications. https://doi.org/10.1101/2021.02.23.432461. Retrieved from https://escholarship.umassmed.edu/faculty_pubs/1930
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.