University of Massachusetts Medical School Faculty Publications


Aging, Frailty, and the Microbiome - How Dysbiosis Influences Human Aging and Disease

UMMS Affiliation

Department of Emergency Medicine; Department of Microbiology and Physiological Systems; Center for Microbiome Research

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Document Type



Digestive System | Environmental Public Health | Gastroenterology | Geriatrics | Medical Microbiology | Microbiology | Pathological Conditions, Signs and Symptoms | Physiology


The human gut microbiome is a collection of bacteria, protozoa, fungi, and viruses that coexist in our bodies and are essential in protective, metabolic, and physiologic functions of human health. Gut dysbiosis has traditionally been linked to increased risk of infection, but imbalances within the intestinal microbial community structure that correlate with untoward inflammatory responses are increasingly recognized as being involved in disease processes that affect many organ systems in the body. Furthermore, it is becoming more apparent that the connection between gut dysbiosis and age-related diseases may lie in how the gut microbiome communicates with both the intestinal mucosa and the systemic immune system, given that these networks have a common interconnection to frailty. We therefore discuss recent advances in our understanding of the important role the microbiome plays in aging and how this knowledge opens the door for potential novel therapeutics aimed at shaping a less dysbiotic microbiome to prevent or treat age-related diseases.


Age-related Diseases, Elderly, Frailty, Inflammation, Microbiome

DOI of Published Version



Haran JP, McCormick BA. Aging, Frailty, and the Microbiome-How Dysbiosis Influences Human Aging and Disease. Gastroenterology. 2021 Jan;160(2):507-523. doi: 10.1053/j.gastro.2020.09.060. Epub 2020 Dec 8. PMID: 33307030. Link to article on publisher's site

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