University of Massachusetts Medical School Faculty Publications

Title

Interactions of APOBEC3s with DNA and RNA

UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology; Schiffer Lab

Publication Date

2021-01-21

Document Type

Article

Disciplines

Biochemistry | Enzymes and Coenzymes | Nucleic Acids, Nucleotides, and Nucleosides | Structural Biology

Abstract

APOBEC3 enzymes are key enzymes in our innate immune system regulating antiviral response in HIV and unfortunately adding diversity in cancer as they deaminate cytosine. Seven unique single and double domain APOBEC3s provide them with unique activity and specificity profiles for this deamination. Recent crystal and NMR structures of APOBEC3 complexes are unraveling the variety of epitopes involved in binding nucleic acids, including at the catalytic site, elsewhere on the catalytic domain and in the inactive N-terminal domain. The interplay between these diverse interactions is critical to uncovering the mechanisms by which APOBEC3s recognize and process their substrates.

Keywords

APOBEC3 enzymes

DOI of Published Version

10.1016/j.sbi.2020.12.004

Source

Maiti A, Hou S, Schiffer CA, Matsuo H. Interactions of APOBEC3s with DNA and RNA. Curr Opin Struct Biol. 2021 Jan 21;67:195-204. doi: 10.1016/j.sbi.2020.12.004. Epub ahead of print. PMID: 33486429. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Current opinion in structural biology

PubMed ID

33486429

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