University of Massachusetts Medical School Faculty Publications

UMMS Affiliation

Meyers Primary Care Institute; Department of Medicine, Division of Geriatric Medicine; Department of Population and Quantitative Health Sciences; Lamar Soutter Library

Publication Date

2020-12-24

Document Type

Article Postprint

Disciplines

Clinical Epidemiology | Epidemiology | Geriatrics | Gerontology | Infectious Disease | Virus Diseases

Abstract

BACKGROUND: Various patient demographic and clinical characteristics have been associated with poor outcomes for individuals with coronavirus disease 2019 (COVID-19). To describe the importance of age and chronic conditions in predicting COVID-19 related outcomes.

METHODS: Search strategies were conducted in PubMed/MEDLINE. Daily alerts were created.

RESULTS: A total of 28 studies met our inclusion criteria. Studies varied broadly in sample size (n=21 to more than 17,000,000). Participants mean age ranged from 48 years to 80 years and the proportion of male participants ranged from 44%-82%. The most prevalent underlying conditions in patients with COVID-19 were hypertension (range: 15% - 69%), diabetes (8% - 40%), cardiovascular disease (4% - 61%), chronic pulmonary disease (1% - 33%), and chronic kidney disease (range 1% - 48%). These conditions were each associated with an increased in-hospital case fatality rate ranging from 1% to 56%. Overall, older adults have a substantially higher case fatality rate (CFR) as compared with younger individuals affected by COVID-19 (42% for those < 65 vs 65% > 65 years ). Only one study examined the association of chronic conditions and the risk of dying across different age groups; their findings suggested similar trends of increased risk in those < 65 and those > 65 years as compared to those without these conditions.

CONCLUSIONS: There has been a traditional, single condition approach to consideration of how chronic conditions and advancing age relate to COVID-19 outcomes. A more complete picture of the impact of burden of multimorbidity and advancing patient age is needed.

Keywords

COVID-19, epidemiology, multimorbidity

Rights and Permissions

© The Author(s) 2020. Accepted Manuscript posted with 12-month embargo as allowed by publisher's self archiving policy at https://academic.oup.com/journals/pages/access_purchase/rights_and_permissions/author_self_archiving_policy. This is a pre-copyedited, author-produced version of an article accepted for publication in J Gerontol A Biol Sci Med Sci. following peer review. The version of record will be available online at https://doi.org/10.1093/gerona/glaa320.

DOI of Published Version

10.1093/gerona/glaa320

Source

Tisminetzky M, Delude C, Hebert T, Carr C, Goldberg RJ, Gurwitz JH. Age, Multiple Chronic Conditions, and COVID-19: A literature review. J Gerontol A Biol Sci Med Sci. 2020 Dec 24:glaa320. doi: 10.1093/gerona/glaa320. Epub ahead of print. PMID: 33367606. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

The journals of gerontology. Series A, Biological sciences and medical sciences

PubMed ID

33367606

Available for download on Friday, December 24, 2021

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