Department of Pathology
Amino Acids, Peptides, and Proteins | Epidemiology | Immunology of Infectious Disease | Immunopathology | Infectious Disease | Microbiology | Virus Diseases
Background: A seroprevalence study can estimate the percentage of people with SARS-CoV-2 antibodies in the general population, however, most existing reports have used a convenience sample, which may bias their estimates.
Methods: We sought a representative sample of Connecticut residents, aged ≥18 years and residing in non-congregate settings, who completed a survey between June 4 and June 23, 2020 and underwent serology testing for SARS-CoV-2-specific IgG antibodies between June 10 and July 29, 2020. We also oversampled non-Hispanic Black and Hispanic subpopulations. We estimated the seroprevalence of SARS-CoV-2-specific IgG antibodies and the prevalence of symptomatic illness and self-reported adherence to risk mitigation behaviors among this population.
Results: Of the 567 respondents (mean age 50 [±17] years; 53% women; 75% non-Hispanic White individuals) included at the state-level, 23 respondents tested positive for SARS-CoV-2-specific antibodies, resulting in weighted seroprevalence of 4.0 (90% confidence interval [CI] 2.0-6.0). The weighted seroprevalence for the oversampled non-Hispanic Black and Hispanic populations was 6.4% (90% CI 0.9-11.9) and 19.9% (90% CI 13.2-26.6), respectively. The majority of respondents at the state-level reported following risk mitigation behaviors: 73% avoided public places, 75% avoided gatherings of families or friends, and 97% wore a facemask, at least part of the time.
Conclusions: These estimates indicate that the vast majority of people in Connecticut lack antibodies against SARS-CoV-2 and there is variation by race/ethnicity. There is a need for continued adherence to risk mitigation behaviors among Connecticut residents to prevent resurgence of COVID-19 in this region.
Seroprevalence, SARS-CoV-2, COVID-19, Antibodies, Connecticut, Epidemiology
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DOI of Published Version
medRxiv 2020.08.04.20168203; doi: https://doi.org/10.1101/2020.08.04.20168203. View preprint on medRxiv
Now published in The American Journal of Medicine doi: 10.1016/j.amjmed.2020.09.024
Mahajan S, Rao LV, Krumholz HM. (2020). Seroprevalence of SARS-CoV-2-Specific IgG Antibodies Among Adults Living in Connecticut: Post-Infection Prevalence (PIP) Study [preprint]. University of Massachusetts Medical School Faculty Publications. https://doi.org/10.1101/2020.08.04.20168203. Retrieved from https://escholarship.umassmed.edu/faculty_pubs/1822
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