UMass Chan Medical School Faculty Publications
UMMS Affiliation
Department of Pathology; Department of Animal Medicine; Graduate School of Biomedical Sciences
Publication Date
2020-09-03
Document Type
Article Preprint
Disciplines
Immunology of Infectious Disease | Immunopathology | Immunoprophylaxis and Therapy | Immunotherapy
Abstract
T follicular helper (TFH) and Cytotoxic CD4 (ThCTL) are tissue-restricted CD4 effector subsets, functionally specialized to mediate optimal Ab production and cytotoxicity of infected cells. Influenza infection generates robust CD4 responses, including lung ThCTL and SLO TFH, that protect against reinfection by variant strains. Antigen (Ag) presentation after infection, lasts through the effector phase of the response. Here, we show that this effector phase Ag presentation, well after priming, is required to drive CD4 effectors to ThCTL and TFH. Using in vivo influenza models, we varied Ag presentation to effectors acutely, just at the effector phase. Ag presentation was required in the tissue of effector residence. We suggest these requirements contain unnecessary or potentially pathogenic CD4 responses, only allowing them if infection is uncleared. The results imply that providing effector phase Ag, would lead to stronger humoral and CD4 tissue immunity and thus can be applied to improve vaccine design.
Keywords
Immunology, Influenza, Cytotoxic CD4, vaccine design, antigens
Rights and Permissions
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
DOI of Published Version
10.1101/2020.09.03.281998
Source
bioRxiv 2020.09.03.281998; doi: https://doi.org/10.1101/2020.09.03.281998. Link to preprint on bioRxiv
Journal/Book/Conference Title
bioRxiv
Repository Citation
Devarajan P, Vong AM, Castonguay CH, Bautista BL, Jones MC, Kugler-Umana O, Kelly KA, Swain SL. (2020). CD4 Effectors Need to Recognize Antigen Locally to Become Cytotoxic CD4 and Follicular Helper T Cells [preprint]. UMass Chan Medical School Faculty Publications. https://doi.org/10.1101/2020.09.03.281998. Retrieved from https://escholarship.umassmed.edu/faculty_pubs/1819
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Included in
Immunology of Infectious Disease Commons, Immunopathology Commons, Immunoprophylaxis and Therapy Commons, Immunotherapy Commons
Comments
This article is a preprint. Preprints are preliminary reports of work that have not been certified by peer review.