University of Massachusetts Medical School Faculty Publications
Title
Factors Influencing Lesion Detection in SPECT Lung Images
UMMS Affiliation
Department of Radiology
Publication Date
2006-10-29
Document Type
Conference Proceeding
Disciplines
Analytical, Diagnostic and Therapeutic Techniques and Equipment | Bioimaging and Biomedical Optics | Biological and Chemical Physics | Nuclear | Nuclear Engineering | Radiology
Abstract
An earlier localization ROC (LROC) study that found attenuation correction (AC) degraded the detection of solitary pulmonary nodules (SPN) in hybrid SPECT lung images had several potential shortcomings related to the simulation methods. We sought to address these issues with a revised LROC study. Clinical Tc-99m NeoTect scans acquired with a simultaneous transmission-emission protocol defined the normal cases in a single-slice LROC study. Abnormal cases contained a simulated 1-cm lung lesion. Four rescaled-block-iterative EM (RBI) reconstruction strategies applied: 1) AC, scatter correction (SC), and resolution compensation (RC); 2) AC only; 3) RC only; and 4) no corrections (NC). Images from these strategies underwent 3D Gaussian post-smoothing. Performances were defined by the average area under the LROC curve obtained from three human observers. The strategy ranking in order of decreasing performance was: 1) RBI with RC; 2) RBI with all corrections; 3) RBI with AC; and 4) RBI with no corrections. A multireader-multicase (MRMC) analysis only found significant patient and patient-strategy effects. The conflicting results concerning AC from this study and the previous one may revolve around lesion masking effects, which, by design, were not a factor in the current study.
Keywords
Lesions, Lungs, Image reconstruction, Attenuation, Protocols, Scattering, Biomedical imaging, Nuclear and plasma sciences, Associate members, Degradation
DOI of Published Version
10.1109/NSSMIC.2006.356429
Source
Gifford HC, Zheng XM, Licho R, Pretorius PH, Schneider PB, Simkin PH, King MA. Factors Influencing Lesion Detection in SPECT Lung Images. IEEE Nucl Sci Symp Conf Rec (1997). 2006;5:2662-2666. doi: 10.1109/NSSMIC.2006.356429. PMID: 19169428; PMCID: PMC2630204. Link to article on publisher's site
Related Resources
Journal/Book/Conference Title
IEEE Nuclear Science Symposium conference record. Nuclear Science Symposium
PubMed ID
19169428
Repository Citation
Gifford HC, Zheng XM, Licho R, Pretorius PH, Schneider PB, Simkin PH, King MA. (2006). Factors Influencing Lesion Detection in SPECT Lung Images. University of Massachusetts Medical School Faculty Publications. https://doi.org/10.1109/NSSMIC.2006.356429. Retrieved from https://escholarship.umassmed.edu/faculty_pubs/1760