University of Massachusetts Medical School Faculty Publications

Title

Location-known-exactly human-observer ROC studies of attenuation and other corrections for SPECT lung imaging

UMMS Affiliation

Division of Nuclear Medicine, Department of Radiology

Publication Date

2006-10-29

Document Type

Conference Proceeding

Disciplines

Analytical, Diagnostic and Therapeutic Techniques and Equipment | Bioimaging and Biomedical Optics | Biological and Chemical Physics | Nuclear | Nuclear Engineering | Radiology

Abstract

We use receiver operating characteristic (ROC) analysis of a location-known-exactly (LKE) lesion detection task to compare the image quality of SPECT reconstruction with and without various combinations of attenuation correction (AC), scatter correction (SC) and resolution compensation (RC). Hybrid images were generated from Tc-99m labelled NeoTect clinical backgrounds into which Monte Carlo simulated solitary pulmonary nodule (SPN) lung lesions were added, then reconstructed using several strategies. Results from a human-observer study show that attenuation correction degrades SPN detection, while resolution correction improves SPN detection, even when the lesion location is known. This agrees with the results of a previous localization-response operating characteristic (LROC) study using the same images, indicating that location uncertainty is not the sole source of the changes in detection accuracy.

Keywords

SPECT, lung imaging, attenuation correction, lesion detection, ROC and LROC analysis

DOI of Published Version

10.1109/NSSMIC.2006.353696

Source

Lehovich A, Gifford HC, King MA. Location-known-exactly human-observer ROC studies of attenuation and other corrections for SPECT lung imaging. IEEE Nucl Sci Symp Conf Rec (1997). 2006;6:3229-3232. doi: 10.1109/NSSMIC.2006.353696. PMID: 19194523; PMCID: PMC2633939. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

IEEE Nuclear Science Symposium conference record. Nuclear Science Symposium

PubMed ID

19194523

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