University of Massachusetts Medical School Faculty Publications

Title

Human-observer LROC study of lesion detection in Ga-67 SPECT images reconstructed using MAP with anatomical priors

UMMS Affiliation

Division of Nuclear Medicine, Department of Radiology

Publication Date

2006-10-29

Document Type

Conference Proceeding

Disciplines

Analytical, Diagnostic and Therapeutic Techniques and Equipment | Bioimaging and Biomedical Optics | Biological and Chemical Physics | Nuclear | Nuclear Engineering | Radiology

Abstract

We compare the image quality of SPECT reconstruction with and without an anatomical prior. Area under the localization-response operating characteristic (LROC) curve is our figure of merit. Simulated Ga-67 citrate images, a SPECT lymph-nodule imaging agent, were generated using the MCAT digital phantom. Reconstructed images were read by human observers. Several reconstruction strategies are compared, including rescaled block iterative (RBI) and maximum-a-posteriori (MAP) with various priors. We find that MAP reconstruction using prior knowledge of organ and lesion boundaries significantly improves lesion-detection performance (p < 0.05). Pseudo-lesion boundaries, regions without increased uptake which are incorrectly treated as prior knowledge of lesion boundaries, do not decrease performance.

Keywords

SPECT reconstruction, anatomical priors, LROC, human observer study

DOI of Published Version

10.1109/NSSMIC.2006.354226

Source

Lehovich A, Bruyant PP, Gifford HC, Schneider PB, Squires S, Licho R, Gindi G, King MA. Human-observer LROC study of lesion detection in Ga-67 SPECT images reconstructed using MAP with anatomical priors. IEEE Nucl Sci Symp Conf Rec (1997). 2006;3:1699-1702. doi: 10.1109/NSSMIC.2006.354226. PMID: 19412357; PMCID: PMC2675947. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

IEEE Nuclear Science Symposium conference record. Nuclear Science Symposium

PubMed ID

19412357

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