University of Massachusetts Medical School Faculty Publications

Title

A point process model of respiratory dynamics in early physiological development

UMMS Affiliation

Department of Neurology

Publication Date

2011-08-30

Document Type

Article

Disciplines

Biomedical Engineering and Bioengineering | Circulatory and Respiratory Physiology | Medical Physiology | Neurology | Physiological Processes | Respiratory System

Abstract

Interbreath interval (IBI), the time interval between breaths, and its variations in time around the mean, the IBI variability, are important measures associated with irregularity of breathing. The IBI histogram generally follows a power law distribution with its characterizing parameters changing with maturation. To assess the dynamics of breathing we propose a point process model of IBI with a lognormal parametric structure to appropriately represent the stochastic nature of the IBI distribution. We estimate the time varying evolution of the characterizing parameters to represent the dynamic nature of breathing, and thereby provide a time-varying measure of irregularity in breathing. The reliability of the model to capture the data is assessed using Kolmogorov-Smirnov (KS) and independence tests. Our results validate the novel approach in the assessment of the irregularity of breathing by analyzing respiratory recordings from newborn rats and preterm infants.

Keywords

interbreath interval, breathing dynamics, irregularity, neurophysiology

DOI of Published Version

10.1109/IEMBS.2011.6090771

Source

Indic P, Paydarfar D, Barbieri R. A point process model of respiratory dynamics in early physiological development. Conf Proc IEEE Eng Med Biol Soc. 2011;2011:3804-7. doi: 10.1109/IEMBS.2011.6090771. PMID: 22255168; PMCID: PMC3340562. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

PubMed ID

22255168

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