University of Massachusetts Medical School Faculty Publications

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Program in Molecular Medicine

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Nuclear Envelope; Nuclear Pore


Molecular Biology | Molecular Genetics


The nuclear envelope forms a cocoon that surrounds the cellular genome keeping it out of harm's way and can be utilized by the cell as a means of functionally regulating chromatin structure and gene expression. At the same time, this double-layered membrane system constitutes a formidable obstacle to the unimpeded flow of genetic information between the genome and the rest of the cell. The nuclear pore has been long considered the sole passageway between nucleus and cytoplasm. A new report challenges this view and proposes a novel mechanism by which RNA transcripts destined for localized translation in highly polarized cell types, cross both inner and outer nuclear envelope membranes and reach the cytoplasm without utilizing the nuclear pore route.

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This is an Open Access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may redistributed, reproduced and reused for non-commercial purposes, provided the original source is properly cited.

DOI of Published Version



Nucleus. 2013 Mar-Apr;4(2):95-9. doi: 10.4161/nucl.24237. Epub 2013 Mar 1. Link to article on publisher's site

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Link to Article in PubMed

Journal/Book/Conference Title

Nucleus (Austin, Tex.)

PubMed ID




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