UMass Chan Medical School Faculty Publications


Multimodality imaging of adult rhabdomyosarcoma: the added value of hybrid imaging

UMMS Affiliation

Department of Radiology; Advanced MRI Center

Publication Date


Document Type



Cancer Biology | Diagnosis | Neoplasms | Oncology | Radiology


Rhabdomyosarcoma (RMS) represents more than 50% of paediatric soft tissue tumours. Conversely, it is extremely rare among adults, where it shows peculiar biological and clinical features that are still poorly investigated. RMS patients should be referred to a Sarcoma Centre, where the contribution of experienced radiologists plays a relevant role in the diagnostic assessment of the disease, including precise localisation, staging, image-guided biopsy, response evaluation after treatment and follow-up. Besides CT and MRI, hybrid imaging including positron emission tomography (PET)/CT and PET/MRI are giving an increasing contribution to provide functional insights about tumour biology and to improve the diagnostic accuracy of the imaging work-up. This review paper provides a revision of the pathology, clinical and radiological features of adult RMS, with a particular focus on the growing role of hybrid PET-based imaging.

DOI of Published Version



Gennaro N, Marrari A, Renne SL, Cananzi FCM, Quagliuolo VL, Di Brina L, Scorsetti M, Pepe G, Chiti A, Santoro A, Balzarini L, Politi LS, Bertuzzi AF. Multimodality imaging of adult rhabdomyosarcoma: the added value of hybrid imaging. Br J Radiol. 2020 Jun 26:20200250. doi: 10.1259/bjr.20200250. Epub ahead of print. PMID: 32559113. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

The British journal of radiology

PubMed ID