Mammalian Near-Infrared Image Vision through Injectable and Self-Powered Retinal Nanoantennae
Department of Biochemistry and Molecular Pharmacology
Nanomedicine | Neuroscience and Neurobiology | Vision Science
Mammals cannot see light over 700 nm in wavelength. This limitation is due to the physical thermodynamic properties of the photon-detecting opsins. However, the detection of naturally invisible near-infrared (NIR) light is a desirable ability. To break this limitation, we developed ocular injectable photoreceptor-binding upconversion nanoparticles (pbUCNPs). These nanoparticles anchored on retinal photoreceptors as miniature NIR light transducers to create NIR light image vision with negligible side effects. Based on single-photoreceptor recordings, electroretinograms, cortical recordings, and visual behavioral tests, we demonstrated that mice with these nanoantennae could not only perceive NIR light, but also see NIR light patterns. Excitingly, the injected mice were also able to differentiate sophisticated NIR shape patterns. Moreover, the NIR light pattern vision was ambient-daylight compatible and existed in parallel with native daylight vision. This new method will provide unmatched opportunities for a wide variety of emerging bio-integrated nanodevice designs and applications. VIDEO ABSTRACT.
biocompatibility, image vision, nanoantenna, near-infrared light, photoreceptors, retina, spectrum, upconversion nanoparticle, visual behavior, visual enhancement
DOI of Published Version
Ma Y, Bao J, Zhang Y, Li Z, Zhou X, Wan C, Huang L, Zhao Y, Han G, Xue T. Mammalian Near-Infrared Image Vision through Injectable and Self-Powered Retinal Nanoantennae. Cell. 2019 Apr 4;177(2):243-255.e15. doi: 10.1016/j.cell.2019.01.038. Epub 2019 Feb 28. PMID: 30827682.
Ma Y, Bao J, Zhang Y, Li ZJ, Zhou X, Wan C, Huang L, Zhao Y, Han G, Xue T. (2019). Mammalian Near-Infrared Image Vision through Injectable and Self-Powered Retinal Nanoantennae. UMass Chan Medical School Faculty Publications. https://doi.org/10.1016/j.cell.2019.01.038. Retrieved from https://escholarship.umassmed.edu/faculty_pubs/1653